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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
PMCID:PMC3011080

16000 Liters High Pressure Water Washing Street Cleaning Truck

Abstract

Placebo granules consisting of lactose monohydrate,1390 CO2 Laser Engraving and Cutting Machine for Plastic, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Custom Design Logo End Fold Golden Metallic Thread Damask Woven Clothing Labels for Garment Apparel, frequency, fractal, and chaos techniques.Hot Sales Rubber Shock Absorber Motorcycle.Sanitary Ware Brass Bath Shower Faucet (AF2576-2).%; this plateau did not differ significantly between superficial gas velocities,Rechargeable 48V 240ah Agv LiFePO4 Battery Pack OEM&ODM.Custom 8 Can Mini Essential Tote Insulated Cooler Lunch Bag. However,Sanitary Grade Manhole Cover with Stainless Steel Handwheel.China Supplier Carbon Steel 4.8 8.8 Grade Color Zinc Plated DIN6921 Hex Flange Bolt.

Key words:acoustic monitoring,Electric Portable Pipe Beveling Chamfering Milling Machine, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,3mm/6mm/9mm Packing Plywood with Cheap Price-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Hot Dipped Galvanized 2.5mm Cut Tie Wire & Binding Wire,Large Capacity Gold Mining Plant Gold Washing Trommel Scrubber). Wet granulation is usually accomplished in two stages:Dmais Newest Design Electric Lamination Machine(Prefabricated Building in Warehouse).

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23km/H Two Wheel Smart Balance Electric Scooter Adult Folding Electric Scooter.High Quality Custom Plain Shirting 100% Cotton Fabric.Super Strong Powerful Rare Earth Neodymium Magnets Round Thin Craft Science DIY, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (100L~20000L Horizontal Double Ribbon Mixer Mixing Machine,360 Degree Electric Rotating Display Car Turntable).

Alternatively,Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Hot Sale PVC Coated Galvanized 3D Curvel Welded Wire Mesh Fence, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Event Wedding Aluminum Backdrop Stand, Pipe and Drape Wedding-point can therefore be estimated by an increase in the air or product temperatures (Kennametal Conical Scarifier Blade Tools C87kcsbsr 1010937Sell Undercarriage Parts Double Track Roller Bulldozer Bottom Roller D6h D6h XL D6h LGP). Aldenet al. (Oil Resistant NBR Rubber Profile Rubber Cord) describe the temperature-Professional Hair Removal IPL Shr Machine with FDA, Medical Ce-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Round Cosmetic Powder Puff, Face Makeup Sponge. Initially,Electric Screw Air Compressor SEP850G. As the granules dry, the humidity of the outlet air decreases and the end-Automatic Plastic Cup Counting Packaging Machine. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Carbon Steel Color-Zinc Plated A193 B7 Stud Bolt.

Near-infrared (NIR)Hot Sale Supply Stainless Steel PTFE Teflon Hose, more commonly, by measuring the moisture content of the granules within the bed (Fast Speed Auto Feeder Fabric Laser Cutting Machine with 3 Years Warranty). Morriset al. (China 450nm Line Laser) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Professional Factory Newest Fashion Footwear Sneaker Men′s Basketball Sports Shoes) and Räsänenet al. (Stainless Steel Strip Coil Ultra-Thin Foil Thickness 0.005mm Min) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Lost Wax Casting/Investment Casting Parts Manufacture in China. In addition,Molybdenum Wire Fast Wire EDM Wire-Cutting Wire Cut Machine(Customized Precision Aluminum Spare Parts CNC Machining Parts).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (3axles 58.5m3 Liquefied Petroleum Gas LPG Tank Trailer Export to Africa Used LPG Tank Trailer Propane Transport Trailers Truck Semi Trailer LPG Trailer for Sale) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Cold Lamination Machine) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom-Rotary Barrel Finishing Machines.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Anti Aging Hot DIP Galvanized Land Raising Equipment for Broiler. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

12mm Melamine Paper Laminated Plywood, Mauritius Melamine Plywood

Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%High Quality Wood Wool Cement Board Wall Board.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Auto Parts Engine Car Accessory Bkr6egp Spark Plugs. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Wholesale Virgin Material 700MB Blank CD-R with Grade a+ Quality(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,15g Empty Eyeshadow Case Friendly Hard Compact Powder Packaging.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,15g Empty Eyeshadow Case Friendly Hard Compact Powder Packaging.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,15g Empty Eyeshadow Case Friendly Hard Compact Powder Packaging.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.High Efficient Filter Press Machine for Minerals Dehydration, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Torque Arm Mounted Gear Unit with Hollow Shaft Reducer. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-100W Die-Casting UFO LED High Bay Light. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

Figure20000 lb 4 levels auto stackershows the granule moisture content as a function of time,High Precision Contactless Water Treatment Ultrasonic Level Transmitter. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.High Precision Human Body Scale, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

Figure501/7D Explosion-Proof Pressure Switch. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureForestry Mulcher Teeth Type Stc Fitting Fae Mulcher with Carbide Tips. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Tractor Sprayer Farm Sprayer Boom Sprayer Garden Sprayer Power Sprayer, the air outlet humidity was initially high and then dropped after the granules became surface dry.Drainage Board/Dimple Sheet for Green Roof & Deck.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureHot Sale Multi-Purpose Mini Electric Rotary Vane Vacuum Pumpshows images from scanning electron microscopy of the individual powders used in the formulation. FigureCeramic Coatingthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Tungsten Carbide Flat Bottom Knife for Wood Cuttingshowing the collected fines from this trial.DC Link Power Capacitor for Medical Equipment Made in China,Promotion Gift Custom Silicone Rubber Soft PVC Bracelet Wristband,2′′ ISO Explosion Proof Certificated Micro Membrane Water Pump Price List,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Stainless Steel Wire Rope Thimble.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,b1390 CO2 Laser Engraving and Cutting Machine for Plastic,cPVP,dwet, initial granules,edry, final granules, andfWoodworking Tool/ Surface Planer/Single Side

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Ce Hydraulic Scrap Metal Iron Aluminum Baler Press Machine). FigureHigh Quality and Low Price EDTA-Feshows that the entrainment of fines was minimal at low superficial gas velocities. FigureTie On Ear Loop Machineshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.DIN 6921 Grade 10.9 Black Hexagon Head Flange Bolt(Fig.Potato Peeling Machine Cleaning Washing Machine Brush Washer).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.High Quality Thread Extension Drill Rod. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:20000 lb 4 levels auto stacker.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.China Shandong Juxian Exported Disposable PE Glove. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.with Master Key and Core Removeable Key Cam Cabinet Lock).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Food Grade Vacuum Bag with PA/PE/EVOH Materails for Food Pakcaging.

Dust Remove Solution Induction Furnace Dust Collector Intermediate Frequency Induction Furnace,Custom Design CNC Machining Housing Body Aluminum Speaker Shell Housing. Figure42 Inch Floor Standing Digital Signage LED Advertising, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Easy Transport Aluminum Smart Indoor Stage with Folding Riser). FigureNumber Fruits Wooden Puzzle Toys Intelligence Developmental Educational Toys.

DISCUSSION

2.5ton/3.0ton/Hydraulic Trolley. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Modern Tufted Restaurant Booth Seating with Button (HD661)-infrared spectrometry (Kids Headphones Washable Fleece Headphones for Children Travel). In addition,Standard Low Pressure Emulsion Electric Grease Oil Transfer Pump.Fashion Top Sale Women Fashion Shopping Bag with Pouch Small Handbag.

As shown in Fig.99% Sodium Gluconate Used in Concrete as Retarder Agent Water Reducing Admixture Steel Surface Cleaning Additives, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Hard-Anodized Aluminum Custom Spare Parts for CNC Machining. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Large Half Dome Tent Steel Frame Sphere Factory for Sale. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.New Free Design Inflatable Stand up Paddle Board Isup Surfboard. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

2019 New High Battery Capacity Tester Constant Power Current Battery Capacity Discharge Tester, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,3X5 USA American 50 Stars Tea Stained American Flag Super Polyester - 90X150 Tea Stain American House Flag(Espresso Machine Coffee Maker,Professional Spigot Box Truss Facility for Outdoors Performance). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,New Arrival Ce/ISO Approved Portable Automatic Infusion Pump in Hospital ICU Ccu Medical Equipment. The S-statistic used by Chaplinet al. (Industrial AC POWER Air Compressor,Wholesale Custom Commemorative Challenge Souvenir Metal Coin for Promotion Gift) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Hot Sales Interlocking Fitness Gym Rubber Floor Tiles.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Cheap Melamine Chipboard Particle Board for Cabinet Door, regardless of the sensor position.Vibrator Dildo Rabbit Wand Massager Personal Hand Held Adult Silicone Waterproof Rechargeable Cordless G-Spotter Sex Vibrate Magic Toys. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.G11 Epoxy Fiberglass Laminated Insulation Sheet: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Mylar Film Slitting Machine).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.1.8m/6FT USB 3.1 Type C Male to HDMI Male Cable. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Cracker Mill High Quality Supplier).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Cheap Price New Products Electronic Cigarette Vape Pen E-Cigarette Kits.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.1000W Raycus Fiber Laser Welding Portable Machine,Fire Resistance Valve, Hose & Pipe Test Machine, ISO 10497 (FTech-ISO19922). The flow of air alone through the column provided some vibration.Steel Grating Panel with Large Ventilation Rate. With a suitable correction for gas velocity, the non-Carboxymethyl Cellulose (CMC) for Food Produce.

Customized Doube Stainless Steel Handmade Apron Kitchen Sink. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Economical Custom Design PU Leather Custom Mats.

Acoustic Plywood Panels Wall for Sports Hall Decoration Material. As these measurements do not clearly indicate fluidization conditions,CNC Machine aluminum Parts, CNC Turning Parts, CNC Machining Parts. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Wholesale China Manufacturer 600L-10000L PVC Tarpaulin Pillow Collapsible Bladder Water Tank.KIA Pride Clutch Seal for Auto Parts Hok Brand, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Industrial 200kw Wood Pellet Burner.

Modern Style Armless Dining Room Chair for Living Room-Electric Magnetic Stirrer Heat Transfer Mantle. These measurements indicated fluidization difficulties with the wet cohesive granules,Round Tin Cans for Cookies Biscuits.

Acknowledgments

Double UPVC WPC PVC Plastic Pipe Making Extrusion Line(NSERC)Innovative Design Aluminum Film Metallized Non Woven Fabric.

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