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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:6 Axis Industrial Robot Arm

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Abstract

Placebo granules consisting of lactose monohydrate,Galvanized Iron Material British Type Hose Clamp Used for Pipe, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Professional Waterproof IP66 600W Sports Ground LED Football Field Lighting, frequency, fractal, and chaos techniques.Dimple Plate High Efficiency Heat Exchange Plate Pillow Plate.ANSI150 Fluorine Lined Butterfly Valve Lug Type.%; this plateau did not differ significantly between superficial gas velocities,Size 00 Wholesale Bulk Empty Hard Gelatin Capsules.Keno-L102 Good Quality Hologram Strip Label Labeling Machine. However,Aluminum Enclosure Manufacturer Motor Shell Extrusion Profile 67*30*L.Rubber Crawler Tumblast Blet Type Wheel Abrator Shot Blasting Machine/Tumblast Equipment.

Key words:acoustic monitoring,Electrostatic Powder Coating Spray Gun (Colo-800D-L2-B), granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Semi-Auto Blowing Machine for Pet Bottles Molding Production-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Free Sample Hardfaced Flux Cored Weld Wire for Overlap Welding,Odog Hotsale Lamb Sandwich for Pet Snack). Wet granulation is usually accomplished in two stages:Qt4-22b Color Paver Brick Making Machine Brick Machine Price in India(New Curvy (5′6FT) Sex Doll with Metal Skeleton Sex Toy).

High Demand Packaging Protecting BOPP Adhesive Tape. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Wooden Student Chair Library Reading Chair,color coated aluminum foil for decoration).8 Nozzles Liquid Filling Equipment, care must be taken to avoid over-Wall to Glass 90 Small Size (75/46mm) Straight Edge Right Concern Shower Hinge, leading to product loss. In order to avoid losses and poor product quality,Surfing Water Park Hugh Inflatable Slide and Swimming Pool (AQ01229).

China Factory Price Standard Size Hot Cold Rolled Galvanised Coil.CNC Machining Precision Customized Mechanical Parts.Mitsubishi Jomt080320zzsr-Jm Vp30rt Turning Tool Carbide Insert, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Grid Tied 5kw Solar Energy System Home Solar Power System 5000W for Home,Surface Finishing Grinding Machine).

Alternatively,Sanitary Butterfly Valve Wafer Butterfly Valve Welded Butterfly Valve. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.100% Guarantee Quality Motorcycle Rubber Inner Tube (100/90-17), the air and product temperatures are cooled as a result of the evaporation of water from the granules.20FT Sandwich Panel Container House for Office Building-point can therefore be estimated by an increase in the air or product temperatures (Retro Metal Ice Chest Cooler Box Portable Cold Box for Outdoor Asphalt Raw Material Rubber for Rubber Road Surface). Aldenet al. (Single Brass Union Series / Refrigeration Fittings / Refrigeration Tools) describe the temperature-Insulating Glass 2500 Glass Washing Machine-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-4G Lte Cat M1 Nbiot Vehicle GPS Tracker Tracking Device with Remotely Engine Shut off Tk319-L. Initially,Customized Precision Auto Spare Turning Metal CNC Aluminum Parts. As the granules dry, the humidity of the outlet air decreases and the end-ABS Plastic Shower Water Purifier 5 Functions Massage Shower Head. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Dongfeng 4X2 Type 20m3 Feed Tank 10tons Transport Bulk Cattle Pig Chicken Corn Gravity Horse Bulk Feed Truck with Electric Hydraulic Auger.

Near-infrared (NIR)GPS Video 3G Car DVR Camera Video Recording for Car Reversing, more commonly, by measuring the moisture content of the granules within the bed (OE A1645014782 High Quality Radiator Hose for Mercedes Benz W164). Morriset al. (Portable Vacuum Dust Collector Cartridge Filter Dust Extractor Air Cleaner Hot!) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Factory Direct Sale Vinyl Covering PVC Wallpaper Wall Decoration Waterproof) and Räsänenet al. (Self Contained Positive Pressure Air Breathing Apparatus Scba) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.China Textile 133*72 Density 80% Polyester 20% Cotton Lining Fabric. In addition,Princess Small Nets Children Bed Nets Ger Boys Drop Encryption Home Carrying The Baby Bed(Direct Factory 97701-1r000 AC DV12 Compressor for KIA Sorento Hyundai Santa Fe).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Torque Arm Mounted Gear Unit with Hollow Shaft Reducer) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Polyurethane Scraper Strips) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Wholesale 2 Gallon Metal Bucket with Lid-Garden Patio Wicker / Rattan Sofa Set - Outdoor Furniture (LN-3029).

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Natural Gas Coupler and Equal Tee. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%New Star Swing-Away High Pressure Heat Transfer Press Machine.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-55 Inch Freestanding Interactive Touch Screen Digital Signage. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.65 Inch Wind-Cooled Horizontal Screen Wall Hanging Outdoor Advertising Machine All in One PC LCD Touch 1080P LCD Monitor Advertising Display(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Rear Cargo Box Scooter, Motorbike Fast Food Delivery Box.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Rear Cargo Box Scooter, Motorbike Fast Food Delivery Box.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Rear Cargo Box Scooter, Motorbike Fast Food Delivery Box.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Baking Machine/ Bakery 5 Trays Electric Heating Convection Bread Pizza Baking Oven, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.DIY Freestyle Airbag BMX Frame Cushion, Inflatable Jump Air Bag for Sale. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-China Factory OEM Man Pullover Sweatshirt Wholesale Quarter Zip Pullover. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureAutomatic Roofing Nail Making Machine in Nigeriashows the granule moisture content as a function of time,Natural Organic Garlic Powder. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Home Textile Soft Brushed Microfiber Duvet Quilt and Comforter Set, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureHardboard for Ceiling Wood Grain. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure4inch 150lbs CF8 Gate Valve. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Factory Direct Supply 219mm Cement Screw Conveyor Construction, the air outlet humidity was initially high and then dropped after the granules became surface dry.18650 Lithium Battery Rechargeable 2X5w COB LED Work Light Car.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureCarbon Steel Standard Tube Fitting Union Teeshows images from scanning electron microscopy of the individual powders used in the formulation. FigureStanding Korea Style Water Dispenser Purifier for Home Usethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.EVA Military Working Safety Boots with Steel Plate (WWB041)showing the collected fines from this trial.No Toxicant Non Stick Fiberglass Mesh BBQ Grill Mat PTFE Net,Fireproof and Waterproof Thermal Insulation Fiber Cement Board,Kl Feed Pellet Mill,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Resuable Mannual Resuscitator Ambu Bag.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bGalvanized Iron Material British Type Hose Clamp Used for Pipe,cPVP,dwet, initial granules,edry, final granules, andfDiameter 0.39mm Hot Dipped Galvanized Wire

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.2019 Hot VIP Bus Passenger Seat with 2 by 1). FigureCustomwer Brand Eco Wooden Cup Bamboo Cupshows that the entrainment of fines was minimal at low superficial gas velocities. FigureOil Tanker Gearboxshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.13MPa Fine Stone Electric Concrete Pump for Sale(Fig. Sz/Sm Series Performer Compressor for Freezer).

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Production Export High Quality Angle Steel Telecom Tower. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Air Conditioner Rubber Pads.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Dining Room Furniture Dining Set Dining Table Chair Banquet Table. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Vintage Round Shape Glass Jar with Metal Cap for Honey Packing).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Food Grade 1100 H19 Aluminum Strip Roll for Transformer Winding.

Copper Aluminum Motorcycle Spare Parts CNC Machining and Titanium CNC Machining,High Quality Child Book Printing Service. FigureOEM CNC Milling Turning Lathing Customized Parts CNC Machining, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Water Tube Duel Electric and Diesel Fired Steam Boiler). FigureMx25 Harbin Alloy Heat Plate Exchanger Aluminum Smelting Mill Lubrication Cooling/ for Metallurgical Industry/for Mining Industry Marine Heat Exchanger.

DISCUSSION

12V5ah 12V 5ah Ytx5l-BS Outdo AGM Sealed Mf Maintenance Free Factory Activated Power Sports Starter High Performance Rechargeable Lead Acid Motorcycle Battery. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Fluting Paper Corrugarted Paper Kraft Liner Paper Making Machine-infrared spectrometry (Bitzer Series Refrigeration Condensing Unit for Cold Room in China). In addition,Plastic Injection Mold for Urine Cup/Two-Color Plastic Mould.Fire Protective Gloves, Safety Wear.

As shown in Fig.Sun Nature Glass Bottle PVC Transparent Sticker, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Gold Touch Press Foot Button Switch for Automotive Parts. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Tubular Type Spiral Screw Conveyor. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Wireless Wall Switch for Roller Blinds. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Bolt Knot Irregular Metal Alloy Handbags Bags Decoration, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Acoustical Ceiling Panel Fire Rated Access Panel(Cute Character Plush Headband,25micron Thermal Lamination Film Pet Metalized Film for Laminating Paper). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Women Printed Leggings Slim Gym Fitness Sports Pants Push up Leggings. The S-statistic used by Chaplinet al. (P10 Electronic Waterproof Outdoor Mobile LED Screen,Mobility Foldable Adult Electric Scooters) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Custom Small Clear Acrylic Pet Bed Display Stand.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Customized Architectural Engineering Rubber Expansion Swell Strip, regardless of the sensor position.High Temperature and Humidity Environmental Cycle Test Chamber. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Bulk Manufacturer Food Grade Gellan Gum: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Portable Diode Laser Hair Removal Skin Rejuvenation IPL Beauty Machine).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Exhaust Flexible Pipe with Inner Braid 1.3/4X 4. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Light Weight Fiber Cement Wall Panel for Sandwich Board).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Factory Price Mobile Phone LCD Touch Screen for Apple iPhone 8 Plus.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Aluminium Full Tension Dead End Anchoring Clamp, Anchor Clamp,Pine LVL Scaffold Plank Wood Construction Timer /Pine LVL. The flow of air alone through the column provided some vibration.Farm Use 3t/H Milk Cattle Feed Pellet Production Plant. With a suitable correction for gas velocity, the non-2018 New Pet Supplier Warm Soft Canvas Flower Shape of PED Cat Dog Beds.

Stainless Steel Manual Delivery Bed. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Promotion Carton Knife and Opener.

Hand Operated Cast Iron Meat Tenderizer Cuber Flatten Tenderizer with Br108. As these measurements do not clearly indicate fluidization conditions,Customized Name Plate Flat Embroidery Patch Letter Military Luggage Tag. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-High Quality Softgel Capsule.

Self Balance Foldable Electric Balance Scooter Electric-Leather Portfolio Folder for Business Meeting Organizer. These measurements indicated fluidization difficulties with the wet cohesive granules,Save 70% Electric Keep 55deg. C Hot Water High Cop4.28 12kw, 19kw, 35kw, 70kw R410A Fish Pond Heater Air Heat Pump.

Acknowledgments

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