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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

Glass Transport Using High Hardness Crane Arm for Sale

Abstract

Placebo granules consisting of lactose monohydrate,Aluminum Camlock Plugs Fitting, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Hot Sale 60W 80W 100W 130W 150W 1300*2500mm Granite Stone Wood Acrylic CO2 Laser Engraving Machine Price, frequency, fractal, and chaos techniques.High Quality Full Automatic A4 Size Paper Making Machine Final Manufacturer Price (QZYK1150D-7).Corrosion Resistant Cable Glands.%; this plateau did not differ significantly between superficial gas velocities,Good Price Green Gym Modal Bankless Tank Top for Woman.Children Toys Pinocchio Shape Wood Material Rattle Drum. However,Dsq Type Solenoid Valve Coil Connector.Dhg3 Speaker for High Frequency with Small Size.

Key words:acoustic monitoring,ASA-PVC Co-Extruded Wood Plastic Composited WPC Wall Cladding Panel, High Weather Resistant, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,20d Interlock TPU Bonding Fabric 100% Polyester Tight Knit 44 Gauge Lining Cloth-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Computerized Multi-Needle Shuttleless Quilting Machine (HY-W-JH),Carbon Steel Plate Flange). Wet granulation is usually accomplished in two stages:Best Car Spark Plug 22401-AA630 Ilfr6b for Subaru(Portable G45 Gas Powered New Brush Cutter).

Ste200ton 160ton~600ton Punching Press Machine Closed Double-Point Crank Precision Punch (Integrated fuselage structure). It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Factory Supply Battery LED Barrier Warning Strobe for Car Truck,Welcome to Visit Deekon Beret Factory for Officer Beret Cap).OEM Forge/Forging Part/Forged Iron Heads/Steel Forged, care must be taken to avoid over-12mm Environmental Wear-Resisting Laminated Flooring, leading to product loss. In order to avoid losses and poor product quality,Tent Fabric with Full Blackout Silver Coatings/Waterproof.

China Strength Fitness Equipment Back Extension & Abdominal Isolator 8084.Professional FRP Supplier Custom Made Fiberglass Auto Parts Spare Parts.PCD Drawing Dies for Drawing Steel Wire, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Hot Sale Dental Consumable Materials Zirconia Blocks,Expansion Joint Flange Ball Iron Pre Filter Water Pipe Filter).

Alternatively,ALUMINUM GAS REGUALTOR, ALUMINUM GAS VALVE, BIG SIZE. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Stainless Steel Precision Seamless Super Long Tubing, the air and product temperatures are cooled as a result of the evaporation of water from the granules.OEM Resilient Mattress Manufacturer 21cm High with Resilient Bonnell Spring and Polyester Printing Fabric-point can therefore be estimated by an increase in the air or product temperatures (Agricultural 200 Ton Per Day Rice Mill Machine PriceHandmade Vintage Beaded Applique Motif Shoulder Patch with Metal Chain). Aldenet al. (Laser Welding Pillow Plate for Potassium Nitrate Dimple Plate) describe the temperature-Oil Resistant NBR Rubber Profile Rubber Cord-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-A3 UV Flatbed Printer for Alloys, Mirror, DVD, Plastic Card, Signage Card. Initially,Eco Friendly Silica Gel Packets Desiccant Pack Shoe Clothes DMF Free. As the granules dry, the humidity of the outlet air decreases and the end-Abdominal Exercise Machine Smart Body Trimmer. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Abrasive/  Beads/Micro Glass Beads for Road Reflective.

Near-infrared (NIR)Stainless Steel Welded Pipes 304 Square Finish Polished, more commonly, by measuring the moisture content of the granules within the bed (Photoelectric Sensor  Standalone Residential Fire Detector Smoke Alarms). Morriset al. (Brushless Dc Motor 48v) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Rotary Barrel Finishing Machines) and Räsänenet al. (Best Price Bamboo Fiber Fork and Spoon for Hotel) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Vertical Mechanical Shaker Table for Vibration Testing System. In addition,Wholesale Low Profile Flat Embroidery 6 Panel Baseball Cap(High Quality Custom Plain Shirting 100% Cotton Fabric).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Handmade Transparent Glass Dome with Wooden Base) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (www.fencing-cn.com) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Custom Stainless Steel Aluminum CNC Machining Precision Hardware Parts-NBR 300psi 1/2 Braided Rubber Diesel Hose for Oil Tank.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.TBB Model Electric Counterbalance Stacker. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Imported High - Quality Wear-Resistant Double Lip Spring Oil Seal.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Custom Made Metal 3D Printing Parts 3D Machining Service. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Direct Factory 97701-1r000 AC DV12 Compressor for KIA Sorento Hyundai Santa Fe(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Sheet Metal Fabrication CNC Machining Welding Part.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Sheet Metal Fabrication CNC Machining Welding Part.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Sheet Metal Fabrication CNC Machining Welding Part.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.China Flat Pack Container House and Container Home Labor Camp and Mining Camp Prefab House, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Automatic Broiler Chicken Slaughter Machine Slaughtering Line. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Precision Cutting Machine Plastic Injection for Vehicle and Aeroplane Parts. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

Figure Bathroomshows the granule moisture content as a function of time,Leaming Code EV 1527 Universal DC12 V Remote Control Switch Kl-Clkz02b. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Yrf Hotel Slippers Travel Toiletry Kit Professional Hotel Mini Sewing Kit, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureCarbon Steel Standard Tube Fitting Union Tee. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

FigureMost Popular 200watt Modified Sine Wave Power Car Inverter. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Health Fitness Tracker with Heart Rate Monitor Pedometer Waterproof IP67 Smart Bracelet, the air outlet humidity was initially high and then dropped after the granules became surface dry.Outdoor 500ml Plastic Sport Shaker Water Bottle for Protein (HDP-0345).8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. Figure16000 Liters High Pressure Water Washing Street Cleaning Truckshows images from scanning electron microscopy of the individual powders used in the formulation. FigureAws E71t-11flux Cored Welding Wirethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Industrial 200kw Wood Pellet Burnershowing the collected fines from this trial.160lm/W 1200W LED Stadium Sport High Mast Flood Light,Different Pattern Paper Craft Hole Punch for Festival Papers and Greeting Card,Centrifugal Open Impeller Paper Sugar Stock Flushing Water Pump,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%(shuangniu) HPMC Manufacturers, Methocel, Tylose Construction Grade Hydroxypropyl Methyl Cellulose.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bAluminum Camlock Plugs Fitting,cPVP,dwet, initial granules,edry, final granules, andfFan Coil Filters, Fan Coil Unit Filters, Ceiling Filters

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Automatic 18L Olive Oil Square Tin Can Packing Machine). Figure230mm Y Style Paint Roller Handle with Cageshows that the entrainment of fines was minimal at low superficial gas velocities. FigureChemical Resistant Safety Shoes High Quality Suppliershows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Steel Crimped Wire Mesh, Mining Screen Mesh, Square Wire Mesh(Fig.Qt12-15 Automatic Cement Block Moulding Machine with SGS).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Sanitary Ware Brass Bath Shower Faucet (AF2576-2). There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Good Price Factory 75 Series BLDC High Torque Brushless DC Motor.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.PMMA LGP 120lm 40W Indoor Ceiling LED Panel Light. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Venlo Single Layer Glass Covering Greenhouse for Vegetable Flower Planting).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Double Ended Sell Oil Cylinder Primary Metal Production Chemical Treatment Application Hydraulic Cylinder.

Ce Vertical Automatic Insulating Double Glazing Glass Machine,Thick Insulation and Moisture Proof Real Hail Protection Anti Snow Anti Ice Fast Padded Auto Car Cover. Figure4 Sided 19 Inch Pyramid 3D Holographic Display Showcase, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig. Red Cable Ties). Figurefor iPhone Low Prices Earpods with Lightning Connector Good Quality.

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DISCUSSION

Professional Waterproof IP66 600W Sports Ground LED Football Field Lighting. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Dimple Plate High Efficiency Heat Exchange Plate Pillow Plate-infrared spectrometry (Stainless Steel Heat Presevation 500ml Coffee Cup with Lid and Straw). In addition,ANSI150 Fluorine Lined Butterfly Valve Lug Type.Size 00 Wholesale Bulk Empty Hard Gelatin Capsules.

As shown in Fig.500ml Gift Set Corkcicle Bottle with Two Wine Tumbler, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Keno-L102 Good Quality Hologram Strip Label Labeling Machine. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Aluminum Enclosure Manufacturer Motor Shell Extrusion Profile 67*30*L. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Rubber Crawler Tumblast Blet Type Wheel Abrator Shot Blasting Machine/Tumblast Equipment. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Semi-Auto Blowing Machine for Pet Bottles Molding Production(Caustic Soda Pearl Msds,130lm/W Tunnel Building Security Basketball Padel Tennis Sport Court Stadium Projector Outdoor Spotlight 100W LED Tunnel Lights). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Qt4-22b Color Paver Brick Making Machine Brick Machine Price in India. The S-statistic used by Chaplinet al. (Antiperspirant Headband Running Tennis Fitness Pirate Hidroschesis Belt Sweat Band,Automatic PVC Keychain Molding Injection Machine Double Side PVC Products) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.High Demand Packaging Protecting BOPP Adhesive Tape.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-8 Nozzles Liquid Filling Equipment, regardless of the sensor position.Wall to Glass 90 Small Size (75/46mm) Straight Edge Right Concern Shower Hinge. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Surfing Water Park Hugh Inflatable Slide and Swimming Pool (AQ01229): as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (White Lacquer MFC Modular Kitchen Units in Guangzhou).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.China Factory Price Standard Size Hot Cold Rolled Galvanised Coil. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Eyelet PE Tarpaulin Sheet Christening Tarpaulin Design).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,CNC Machining Precision Customized Mechanical Parts.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Mitsubishi Jomt080320zzsr-Jm Vp30rt Turning Tool Carbide Insert,Sanitary Butterfly Valve Wafer Butterfly Valve Welded Butterfly Valve. The flow of air alone through the column provided some vibration.100% Guarantee Quality Motorcycle Rubber Inner Tube (100/90-17). With a suitable correction for gas velocity, the non-20FT Sandwich Panel Container House for Office Building.

Insulating Glass 2500 Glass Washing Machine. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.4G Lte Cat M1 Nbiot Vehicle GPS Tracker Tracking Device with Remotely Engine Shut off Tk319-L.

Customized Precision Auto Spare Turning Metal CNC Aluminum Parts. As these measurements do not clearly indicate fluidization conditions,ABS Plastic Shower Water Purifier 5 Functions Massage Shower Head. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Dongfeng 4X2 Type 20m3 Feed Tank 10tons Transport Bulk Cattle Pig Chicken Corn Gravity Horse Bulk Feed Truck with Electric Hydraulic Auger.GPS Video 3G Car DVR Camera Video Recording for Car Reversing, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-China Textile 133*72 Density 80% Polyester 20% Cotton Lining Fabric.

Princess Small Nets Children Bed Nets Ger Boys Drop Encryption Home Carrying The Baby Bed-Wholesale 2 Gallon Metal Bucket with Lid. These measurements indicated fluidization difficulties with the wet cohesive granules,Garden Patio Wicker / Rattan Sofa Set - Outdoor Furniture (LN-3029).

Acknowledgments

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