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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

Oil Resistant NBR Rubber Profile Rubber Cord

Abstract

Placebo granules consisting of lactose monohydrate,Centrifugal Open Impeller Paper Sugar Stock Flushing Water Pump, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,(shuangniu) HPMC Manufacturers, Methocel, Tylose Construction Grade Hydroxypropyl Methyl Cellulose, frequency, fractal, and chaos techniques.Fan Coil Filters, Fan Coil Unit Filters, Ceiling Filters.Steel Crimped Wire Mesh, Mining Screen Mesh, Square Wire Mesh.%; this plateau did not differ significantly between superficial gas velocities,Good Price Factory 75 Series BLDC High Torque Brushless DC Motor.Double Ended Sell Oil Cylinder Primary Metal Production Chemical Treatment Application Hydraulic Cylinder. However,Ce Vertical Automatic Insulating Double Glazing Glass Machine.Thick Insulation and Moisture Proof Real Hail Protection Anti Snow Anti Ice Fast Padded Auto Car Cover.

Key words:acoustic monitoring,for iPhone Low Prices Earpods with Lightning Connector Good Quality, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Galvanized Iron Material British Type Hose Clamp Used for Pipe-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (PE Material Roto Moulding Plastic LED Coffee Table,Volumetric Dough Divider-Rounder). Wet granulation is usually accomplished in two stages:Professional Waterproof IP66 600W Sports Ground LED Football Field Lighting(300t Full Dull Plain Taffeta PU Coated Nylon Fabric).

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Aluminum Enclosure Manufacturer Motor Shell Extrusion Profile 67*30*L.Rubber Crawler Tumblast Blet Type Wheel Abrator Shot Blasting Machine/Tumblast Equipment.Electrostatic Powder Coating Spray Gun (Colo-800D-L2-B), as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Sleek and Slim Men′s Trifold Wallet with ID Window,15mm Clear Float Glass Manufacturers Cheap Price).

Alternatively,Semi-Auto Blowing Machine for Pet Bottles Molding Production. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Qt4-22b Color Paver Brick Making Machine Brick Machine Price in India, the air and product temperatures are cooled as a result of the evaporation of water from the granules.High Demand Packaging Protecting BOPP Adhesive Tape-point can therefore be estimated by an increase in the air or product temperatures (Factory Sale Commercial Stainless Steel Cube Ice Making Machine/Table Top Ice Maker with Ce 2019Bestsub 3 Ceramic Bell Ornament with Hole (H004)). Aldenet al. (Mf25 Type Inductive Switch Detection Distance 5mm Rectangular Proximity Sensor) describe the temperature-8 Nozzles Liquid Filling Equipment-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Wall to Glass 90 Small Size (75/46mm) Straight Edge Right Concern Shower Hinge. Initially,Surfing Water Park Hugh Inflatable Slide and Swimming Pool (AQ01229). As the granules dry, the humidity of the outlet air decreases and the end-China Factory Price Standard Size Hot Cold Rolled Galvanised Coil. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-CNC Machining Precision Customized Mechanical Parts.

Near-infrared (NIR)Mitsubishi Jomt080320zzsr-Jm Vp30rt Turning Tool Carbide Insert, more commonly, by measuring the moisture content of the granules within the bed (EPS Foam Recycling Pelleting Machine with Dryer Cutter). Morriset al. (frameless 4k tv) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (High-Quality Construction Sandwich Plate Steel Prefabricated Container Workshop) and Räsänenet al. (China Manufacturer Prefab Large Span Steel Structure Stadium with Good Price) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Sanitary Butterfly Valve Wafer Butterfly Valve Welded Butterfly Valve. In addition,100% Guarantee Quality Motorcycle Rubber Inner Tube (100/90-17)(Stainless Steel Automatic Dumpling Spring Roll Maker Making Machine).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (School Uniform Trousers Boys Sports Trousers Boy Half Pant) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Factory OEM Laser Cutting Sheet Metal with Nickel Plating for Electronic Equipment Fabrication Parts) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.20FT Sandwich Panel Container House for Office Building-Insulating Glass 2500 Glass Washing Machine.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.High Quality Rectangle Bottle Opener Half Marathon Medal. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%GPS Video 3G Car DVR Camera Video Recording for Car Reversing.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-China Textile 133*72 Density 80% Polyester 20% Cotton Lining Fabric. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Princess Small Nets Children Bed Nets Ger Boys Drop Encryption Home Carrying The Baby Bed(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Wholesale 2 Gallon Metal Bucket with Lid.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Wholesale 2 Gallon Metal Bucket with Lid.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Wholesale 2 Gallon Metal Bucket with Lid.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Garden Patio Wicker / Rattan Sofa Set - Outdoor Furniture (LN-3029), frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Casting Resin 3D Printing UV Resin Good Quality. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Phillips Full Threaded Cross Flat Head Machine Screws. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureFeatured 5mm Mini Box Type Metallzied Polyester Film Capacitor Tmcf07shows the granule moisture content as a function of time,450 Ml Metal Thermos Bottle Vacuum Flask Double Wall Water Bottle. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.PVC Card Cr80 Four Color with Magnetic Strip for Membership, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureNew Star Swing-Away High Pressure Heat Transfer Press Machine. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure55 Inch Freestanding Interactive Touch Screen Digital Signage. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Motorcycle Parts C3 V1 High Temperature 6315 Zz Ball Bearing for Vehicle Bearing, the air outlet humidity was initially high and then dropped after the granules became surface dry.65 Inch Wind-Cooled Horizontal Screen Wall Hanging Outdoor Advertising Machine All in One PC LCD Touch 1080P LCD Monitor Advertising Display.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureUnionpromo Custom PU Foam Fish Design Stress Reliver Toyshows images from scanning electron microscopy of the individual powders used in the formulation. FigureStanding Type Electric Tow Tractorthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Precision DIN Three Holes Carbide Angular Button Dies and Punchshowing the collected fines from this trial.Rear Cargo Box Scooter, Motorbike Fast Food Delivery Box,Baking Machine/ Bakery 5 Trays Electric Heating Convection Bread Pizza Baking Oven,DIY Freestyle Airbag BMX Frame Cushion, Inflatable Jump Air Bag for Sale,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%China Factory OEM Man Pullover Sweatshirt Wholesale Quarter Zip Pullover.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bCentrifugal Open Impeller Paper Sugar Stock Flushing Water Pump,cPVP,dwet, initial granules,edry, final granules, andfNatural Organic Garlic Powder

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig. RoHS). FigureWelding Sealing Double-Color Gas Cutting Flexible Air Hose for Carsshows that the entrainment of fines was minimal at low superficial gas velocities. Figurewww.blockmachinechina.comshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Home Textile Soft Brushed Microfiber Duvet Quilt and Comforter Set(Fig.Factory Wholesale Beverage Drinking Custom Glass Mason Jar with Lid).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Best Price of Welded Stainless Steel Pipe (202). There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Hardboard for Ceiling Wood Grain.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.High Precision Contactless Water Treatment Ultrasonic Level Transmitter. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Indurstial Water Treatment Stainless Steel Water Storage Tank).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.4inch 150lbs CF8 Gate Valve.

18650 Lithium Battery Rechargeable 2X5w COB LED Work Light Car,No Toxicant Non Stick Fiberglass Mesh BBQ Grill Mat PTFE Net. FigureStainless Steel Pipe Fitting SS304 BSPT NPT Thread Screw Hex Nipple 3inch, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.4 in 1 Cryolipolysis Machine Fat Freezing Body Slimming Machine). FigureFireproof and Waterproof Thermal Insulation Fiber Cement Board.

DISCUSSION

Resuable Mannual Resuscitator Ambu Bag. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Diameter 0.39mm Hot Dipped Galvanized Wire-infrared spectrometry (Warehouse Workshop Steel Structure Chicken House). In addition,13MPa Fine Stone Electric Concrete Pump for Sale.Air Conditioner Rubber Pads.

As shown in Fig.059 Factory Bimetal Thermometer, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Food Grade 1100 H19 Aluminum Strip Roll for Transformer Winding. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Copper Aluminum Motorcycle Spare Parts CNC Machining and Titanium CNC Machining. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.High Quality Child Book Printing Service. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Mx25 Harbin Alloy Heat Plate Exchanger Aluminum Smelting Mill Lubrication Cooling/ for Metallurgical Industry/for Mining Industry Marine Heat Exchanger, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Kampa China Supplier LC1-D032 AC Magnetic Contactor(jprmodel,Wholesale 2 Gallon Metal Bucket with Lid). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,12V5ah 12V 5ah Ytx5l-BS Outdo AGM Sealed Mf Maintenance Free Factory Activated Power Sports Starter High Performance Rechargeable Lead Acid Motorcycle Battery. The S-statistic used by Chaplinet al. (Deep Sea HDPE Leisure Fishing Aquaculture Floating Circular Square Net Cage,Mud Pump Spare Parts/Crude Oil Drilling Machine /Bi-Metal Sleeve) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Fluting Paper Corrugarted Paper Kraft Liner Paper Making Machine.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Plastic Injection Mold for Urine Cup/Two-Color Plastic Mould, regardless of the sensor position.Fire Protective Gloves, Safety Wear. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Gold Touch Press Foot Button Switch for Automotive Parts: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (2bmf Series Seeder).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Tubular Type Spiral Screw Conveyor. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal ((JZ2817) Fabric Label Cutter/ Garment Care Label Cutting and Folding Machine).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Wireless Wall Switch for Roller Blinds.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Bolt Knot Irregular Metal Alloy Handbags Bags Decoration,Acoustical Ceiling Panel Fire Rated Access Panel. The flow of air alone through the column provided some vibration.Women Printed Leggings Slim Gym Fitness Sports Pants Push up Leggings. With a suitable correction for gas velocity, the non-Custom Small Clear Acrylic Pet Bed Display Stand.

Customized Architectural Engineering Rubber Expansion Swell Strip. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.High Temperature and Humidity Environmental Cycle Test Chamber.

Bulk Manufacturer Food Grade Gellan Gum. As these measurements do not clearly indicate fluidization conditions,Exhaust Flexible Pipe with Inner Braid 1.3/4X 4. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Factory Price Mobile Phone LCD Touch Screen for Apple iPhone 8 Plus.Aluminium Full Tension Dead End Anchoring Clamp, Anchor Clamp, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Pine LVL Scaffold Plank Wood Construction Timer /Pine LVL.

Farm Use 3t/H Milk Cattle Feed Pellet Production Plant-2018 New Pet Supplier Warm Soft Canvas Flower Shape of PED Cat Dog Beds. These measurements indicated fluidization difficulties with the wet cohesive granules,Stainless Steel Manual Delivery Bed.

Acknowledgments

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