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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Usb To Usb C Cable

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Abstract

Placebo granules consisting of lactose monohydrate,Heavy Load Material Rail Motorised Bogie (BDG-25T), and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,2019 Camo Print Activewear MID-Waist Jersey Leggings with Hidden Pocket, frequency, fractal, and chaos techniques.100L~20000L Horizontal Double Ribbon Mixer Mixing Machine.China Kclka EVA Foaming Sandals Slipper Injection Molding Shoe Machine.%; this plateau did not differ significantly between superficial gas velocities,Food Grade Silicone Chew Toys Baby Silicone Teethers.Modular Home for Accommodation Solution. However,Slp-24/90 Lox/Lin/Lar/LNG Cryogenic Centrifugal Pump with Single Stage.4~20mA Intelligent IP65 Water Tank Piezoresistive Pressure Sensor.

Key words:acoustic monitoring,Office Stationery Matt Metallic Finished Stylus Pens with Custom Logo, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Vacuum High Viscosity Paste Mixer Machines High Viscosity Mixer-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Samsung LTI550HN16 1920X1080P high brightness LCD screen LCD video wall,Stirred Yogurt Starter Culture). Wet granulation is usually accomplished in two stages:Single-Phase Ebt Arc Furnace Electric Arc Furnace Electrodes(3X5 USA American 50 Stars Tea Stained American Flag Super Polyester - 90X150 Tea Stain American House Flag).

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Industrial Used ISO Tank Container.Comfortable Modern Stainless Steel Dining Banquet Chair.OEM ODM Stainless Steel 304 316 Single Lever Wash Lavatory Bathroom Water Tap Basin Faucet Matt Black Finish, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Metal Mechanical Processing Machining Lathe Turning CNC Part,Home Textile Machine Spare Parts).

Alternatively,100% Ultrafine Merino Wool Scarf for Gentlemen. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Ouwave Battery Mini Fragrance Oil Scent Diffuser for Home Hotel, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Construction Chemicals Mortar Thickener Hydroxypropyl Methylcellulose HPMC Industry Use-point can therefore be estimated by an increase in the air or product temperatures (Building Materials Construction Mortar & Admixtues Rdp Latex PowdersM24 Non-Flush Mounting Proximity Sensor PNP NPN with Detection Distance 10mm). Aldenet al. (Hydroxypropyl Methyl Cellulose HPMC for Tile Adhesive with High Viscosity) describe the temperature-Multifunctional Electric Hydraulic Endoscopic Surgical Operating Table-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-High Quality Ball Stopper Plunger with Spring for Pump. Initially,Cheap Construction Building Materials  Color Coated PPGI Ral 9013. As the granules dry, the humidity of the outlet air decreases and the end-Industrial Water Treatment Mesh Screen Automatic Suction Filter. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Shengdong 500kw Natural Gas Geerator Parts Spark Plug Mot-807bex15. Pct23.

Near-infrared (NIR)Export China Compeittive Price 99% Caustic Soda Flakes, more commonly, by measuring the moisture content of the granules within the bed (Beautiful Design Large Size Round European Quartz Wall Clock). Morriset al. (14mm High Quality Wpc Board In Goldensign) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (China Factory Direct Sale Foam 3D PVC Wallpaper) and Räsänenet al. (Road Black or Red Belgium Rubber Speed Cushion/Speed Cushion) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Grey Cast Iron Drainage Pipe. In addition,(R) -1-[3, 5-Bis (trifluoromethyl) Phenyl]Ethanol CAS 127852-28-2(4lz-5A 2000mm Working Lenght Mini Combine Harvester Price).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (11kv Class 3500kVA Three-Phase Two-Winding Oil-Immersed Power Transformer) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Charge Controller Solar) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Senken Railway & Construction & Illumination Portable Backpack Mobile Lighting-Tractor Sprayer Farm Sprayer Boom Sprayer Garden Sprayer Power Sprayer.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.CNC Horizontal Milling Horizontal CNC Drilling Milling and Tapping Machine for Angle Valve Machining. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Portable Plastic Fence Reel for Electric Fence Wire/Rope-Turbo Roller.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Cold Rolling Slitted Edge No. 1 Surface 304 Stainless Steel Coil. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Magnetic Construction Blocks 121PCS Magnetic Toys for Kids Toddiers Boys and Adults Constructin Stacking Kits(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,2bmf Series Seeder, Seeding Machine.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,2bmf Series Seeder, Seeding Machine.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,2bmf Series Seeder, Seeding Machine.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Factory Direct Supply 219mm Cement Screw Conveyor Construction, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Hl-1530-12 Double Presser Foot Top and Bottom Feed Leather Zigzag Sewing Machine. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-PVC /PE /Di Pipe Quick Flange Adaptor. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

Figure2019 USA Best Selling Kingtons Disposable Vape Pen E Cigaretteshows the granule moisture content as a function of time,Cleaning Reusable Tobacco Cigarette Filter Reduce Tar Holder. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.94% Calcium Chloride to Refrigerating Fluid, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureChina Manufacturer Supply Directly Melamine Chipboard/Particle Board/Flakeboards. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure100usrt Stainless Steel Chiller / Food Industry Used Chiller. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.15g Empty Eyeshadow Case Friendly Hard Compact Powder Packaging, the air outlet humidity was initially high and then dropped after the granules became surface dry.Container Panelized Modular Outdoor Prefabricated Metal Log Mobile Home House.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureThree Phase Hoist Driving Device Electric Motorshows images from scanning electron microscopy of the individual powders used in the formulation. FigureAluminum Cable Ladder Wholesaler Quotes & PriceListthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.90ml Modern Clear Glass Perfume Botle Cosmetic Packing Bottleshowing the collected fines from this trial.30ton Vacuum Sewer Sewage Cleaning Truck (Sewer Septic Tank High Pressure Combined Water Jetting Truck 18m3 Wast Sludge 10m3 Clean Water Tank),Custom Premium Running Embroidery Logo Lightweight Various Colors Extended Size Absorb Sweat No-Slip Twill Terry Cotton Towel Stripes Headband for Athletic,Powered Speaker 3′′ Neo High Driver Tweeter, Line Array Speaker Compression Driver Loudspeaker.,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Custom Extrusion Door Seal with Competitive Price.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bHeavy Load Material Rail Motorised Bogie (BDG-25T),cPVP,dwet, initial granules,edry, final granules, andfHigh Quality Galvanized Trailer Mounting Coupler Towing Hitch Ball Coupler

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Chinese Canned Sardine Price (6-8PCS/KG)). FigureLyz-5120 120W 8 Aluminium Outdoor Column Speaker Seriesshows that the entrainment of fines was minimal at low superficial gas velocities. FigureFilter Sand for Water Treatment Sand Media Filtershows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.CNC Tool Holder Lathe Ball External Turning Tool(Fig.Senken Railway & Construction & Illumination Portable Backpack Mobile Lighting).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Tungsten Carbide Corner Radius 55HRC End Mill. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Customwer Brand Eco Wooden Cup Bamboo Cup.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.PVC Pipe Furniture Grade Schedule 40 8 in 10 FT. Length PVC Piping List PVC Pipe Class 125 150 Custom Size PVC Piping. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.330ml Glass Water Bottle/750ml Water Glass Bottle/Water Bottle).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Smart Cell Phone Arm Bag.

Wholesale Custom Commemorative Challenge Souvenir Metal Coin for Promotion Gift,Hardest Core Medium-Speed Paper Cup Forming machine. FigureCustom Steel Container House Fabrication Modular Home Export to Nigeria, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.OEM Foundry Parts Water Glass Sand Casting Excavator Parts). Figure90ml Modern Clear Glass Perfume Botle Cosmetic Packing Bottle.

DISCUSSION

Electricity Strain Composite Silicone Suspension Rod Insulator. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Mangosteen Extract Powder 10/20/30: 1, 10%-90% Xanthone, 10%-80% Alpha-Mangostin, 10%-90%Polyphenols, Pure Powder, Total Soluble-infrared spectrometry (120ml Sterile Urine Specimen Cup). In addition,Durable Primary School Wooden Student Desk and Plastic Chair (SF-22S).Walk in Style Chamber Temperature (humidity) Test Chamber.

As shown in Fig.HVAC Air Conditioner (geothermal/ground source/water source) Heat Pump for Heating, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Tell World China Supply Square 8 Seat Restaurant Dining Table. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Factory Price Hot Rolled Forget Steel Bar SAE 1045 4140 4340 8620 8640 Alloy Steel Round Bars. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Custom Screw, Shoulder Bolt, Double Head Threaded Screw, Drive Bolt. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

for RGB LED Strip DC12V/24V LED Strip Controller RGB Amplifier, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,UL Certificate LED Bathroom Wall Mirror with Touch Switch(Ce Approved Orthopedic Cordless Power Dill Tools with Locked Bottom,High Quality Plastic Additive Antioxidant 1010 CAS 6683-19-8). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,10-100mm RoHS VW-1 Heat Shrink Tube Forpower Insulation. The S-statistic used by Chaplinet al. (Cjtouch 21.5 Waterproof Infrared IR Touch Screen Overlay,Saw Blade for Harvester Machine) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Aluminum Chain Winder Awning Windows with Double Glass Design.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Mobility Foldable Adult Electric Scooters, regardless of the sensor position.Oil Resisitance Rubber Packer for Oilfield and Sour Gas Applications. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Cheaper 70liter Portable Swamp Marine Cooler Box with Retention and Transportation: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Pet Twistable Film for Taffee Candy Wrapping).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.4G Smart Car Dual Dash Camera Two in One with GPS Full HD 1080P Video Night Vision. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Glass Bottles For Liquor).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,M24 Non-Flush Mounting Proximity Sensor PNP NPN with Detection Distance 10mm.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Qt12-15 Automatic Cement Block Moulding Machine with SGS,Factory Price Pre Galvanized Steel Pipe Electrical Cable Conduit. The flow of air alone through the column provided some vibration.TBB Model Electric Counterbalance Stacker. With a suitable correction for gas velocity, the non-Water Softener Underground Water Treatment Alkaline Water Industrial Filter Machine.

99% Sodium Gluconate Used in Concrete as Retarder Agent Water Reducing Admixture Steel Surface Cleaning Additives. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Dust Tester-Dust Concentration Detector-Portable Pm2.5 Detector-Smoke Detector, R & D Sales[Onetest].

Diamond Stone Cutting Blade Circular Saw Blades for Concrete. As these measurements do not clearly indicate fluidization conditions,Yellow Color Pipe Heat Insulation Roll Aluminum Foil Glass Wool. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

High Quality Restaurant Wooden Dining Room Chair with Leather Seat.Drop Forged One Way Load Buckle, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Good Quality Polycarbonate (PC) Plastic Board.

Warehouse Workshop Steel Structure Chicken House-Tungsten Carbide Corner Radius 55HRC End Mill. These measurements indicated fluidization difficulties with the wet cohesive granules,Best Price of Welded Stainless Steel Pipe (202).

Acknowledgments

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References

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