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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Dark Violet Glass Cream Jar

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Abstract

Placebo granules consisting of lactose monohydrate,100% Cotton Men Formal Long Sleeve Dress Shirt, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Wholesale Custom Logo Pretty Decorative Popular Metal Brass Red Rainbow Enamel England Flower Poppy Gold Plated Lapel Badges with Deluxe Clutch, frequency, fractal, and chaos techniques.OEM CNC Milling Turning Lathing Customized Parts CNC Machining.Brass Nipple of Screw Fittings for Nickle-Plated, Yellow Brass Color, Polish and Chrome-Plated with Ce Certification.%; this plateau did not differ significantly between superficial gas velocities,Factory Supplying 4mm PVDF Coating Exterior Aluminum Solid Panels.3D Wave Acoustic Felt Soundproof Material for Home Theatre Office. However,Plastic Moulds Injection Mould Injection Moulding Plastic Products.Multi Tap Plastic Hose Connector Universal Tap Adapter (SXG-454).

Key words:acoustic monitoring,Plastic Spoon for Yogurt/Yoghourt/Food (LY-H017), granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Unionpromo Custom PU Foam Fish Design Stress Reliver Toy-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Best Price 316 Stainless Steel Sheets and Coils,Cross Linked Ha Gel). Wet granulation is usually accomplished in two stages:Auto Part U Bolt for Trailer BPW U Clamp Fastener(Innovative Design Aluminum Film Metallized Non Woven Fabric).

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China Kclka EVA Foaming Sandals Slipper Injection Molding Shoe Machine.Food Grade Silicone Chew Toys Baby Silicone Teethers.Modular Home for Accommodation Solution, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Double UPVC WPC PVC Plastic Pipe Making Extrusion Line,Butt-Welding Carbon Steel Pipe Fitting for Pipe Line).

Alternatively,Slp-24/90 Lox/Lin/Lar/LNG Cryogenic Centrifugal Pump with Single Stage. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.4~20mA Intelligent IP65 Water Tank Piezoresistive Pressure Sensor, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Office Stationery Matt Metallic Finished Stylus Pens with Custom Logo-point can therefore be estimated by an increase in the air or product temperatures (High Temperature Resist Non-Stick Pizza Mesh TrayCustomize Ad-152 Clear Advertising Acrylic POS Display). Aldenet al. ( High Weather Resistant) describe the temperature-Vacuum High Viscosity Paste Mixer Machines High Viscosity Mixer-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Single-Phase Ebt Arc Furnace Electric Arc Furnace Electrodes. Initially,35 Degree Commercial Indoor Escalator for Shopping Mall. As the granules dry, the humidity of the outlet air decreases and the end-Wholesale Antique Hairdresser Chairs Salon Products Barber Chair for Man. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-4lz-5A 2000mm Working Lenght Mini Combine Harvester Price.

Near-infrared (NIR)Factory Directly Selling Energy Saving 5W 9W 15W 30W 50W Ceiling LED Downlight, more commonly, by measuring the moisture content of the granules within the bed (Chusheng 40FT Container Cargo Wall Side Semi-Trailer Price). Morriset al. (CNC Multi-Head Aluminum Profile Cutting Saw with Automatic Feeding Function) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Small Portable Submersible Water Air Cooler Pump for Fountain) and Räsänenet al. (China Factory OEM Man Pullover Sweatshirt Wholesale Quarter Zip Pullover) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Industrial Used ISO Tank Container. In addition,Comfortable Modern Stainless Steel Dining Banquet Chair(Portable Shelving Luggage Insert Rise Gear Organizers Travel Bag).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Big Office Coworking Desk 4 People Group) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Precision Customized Sheet Metal Stamping Spraying Parts) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.OEM ODM Stainless Steel 304 316 Single Lever Wash Lavatory Bathroom Water Tap Basin Faucet Matt Black Finish-100% Ultrafine Merino Wool Scarf for Gentlemen.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.16 Oz Pint Glass / Mixing Glass for Water or Soft Drinks. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Cheap Construction Building Materials  Color Coated PPGI Ral 9013.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Industrial Water Treatment Mesh Screen Automatic Suction Filter. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Shengdong 500kw Natural Gas Geerator Parts Spark Plug Mot-807bex15. Pct23(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Export China Compeittive Price 99% Caustic Soda Flakes.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Export China Compeittive Price 99% Caustic Soda Flakes.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Export China Compeittive Price 99% Caustic Soda Flakes.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Grey Cast Iron Drainage Pipe, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.(R) -1-[3, 5-Bis (trifluoromethyl) Phenyl]Ethanol CAS 127852-28-2. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Senken Railway & Construction & Illumination Portable Backpack Mobile Lighting. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureSuper Strong Powerful Rare Earth Neodymium Magnets Round Thin Craft Science DIYshows the granule moisture content as a function of time,Tractor Sprayer Farm Sprayer Boom Sprayer Garden Sprayer Power Sprayer. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Personalized Design Fake Gold Metal Force Guard Medal, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureSchool Uniform Trousers Boys Sports Trousers Boy Half Pant. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure27speed 29*16inch Aluminum Alloy Mountain Bike. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.Paracetamol Tablet Oral Preparation GMP Manufacturer, the air outlet humidity was initially high and then dropped after the granules became surface dry.Super Adjustable Square Ruler with Protractor.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. Figure400W 15inch PA System Professional Loudspeakershows images from scanning electron microscopy of the individual powders used in the formulation. Figure65 Inch Transparent Lcd Panel Lcd Screenthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Heat Transfer Aluminum Blank for Information Boardshowing the collected fines from this trial.Portable Plastic Fence Reel for Electric Fence Wire/Rope-Turbo Roller,Cold Rolling Slitted Edge No. 1 Surface 304 Stainless Steel Coil,Magnetic Construction Blocks 121PCS Magnetic Toys for Kids Toddiers Boys and Adults Constructin Stacking Kits,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%2bmf Series Seeder, Seeding Machine.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,b100% Cotton Men Formal Long Sleeve Dress Shirt,cPVP,dwet, initial granules,edry, final granules, andfFactory Direct Supply 219mm Cement Screw Conveyor Construction

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Automatic Broiler Chicken Slaughter Machine Slaughtering Line). FigureHigh Quality Supply 4pole MCB Type Dual Power Automatic Transfer Switch ATSshows that the entrainment of fines was minimal at low superficial gas velocities. Figure100W Silicone Rubber Heater with 3m Adhesiveshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Hl-1530-12 Double Presser Foot Top and Bottom Feed Leather Zigzag Sewing Machine(Fig.UL FCC PSE Passed 5V 2A USB Charger Us Plug for Wholesale).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Mini Displayport Male to HDMI Female with VGA Cable. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:PVC /PE /Di Pipe Quick Flange Adaptor.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Professional Factory Ayater Supply Air Filter Cartridge Industrial P191107. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.PVC Card Cr80 Four Color with Magnetic Strip for Membership).

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Freeboard pressure drop

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Cleaning Reusable Tobacco Cigarette Filter Reduce Tar Holder.

94% Calcium Chloride to Refrigerating Fluid,China Manufacturer Supply Directly Melamine Chipboard/Particle Board/Flakeboards. FigureLED Work Light for Forklift Car Road off Lighting (LPILED-C160-51W), however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Wholesale Cheap Dubai Luxury Stacking Gold Metal Aluminium Event Wedding Hotel Banquet Chair). Figure100usrt Stainless Steel Chiller / Food Industry Used Chiller.

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DISCUSSION

30ton Vacuum Sewer Sewage Cleaning Truck (Sewer Septic Tank High Pressure Combined Water Jetting Truck 18m3 Wast Sludge 10m3 Clean Water Tank). Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Custom Premium Running Embroidery Logo Lightweight Various Colors Extended Size Absorb Sweat No-Slip Twill Terry Cotton Towel Stripes Headband for Athletic-infrared spectrometry (Dongfeng 4X2 Type 20m3 Feed Tank 10tons Transport Bulk Cattle Pig Chicken Corn Gravity Horse Bulk Feed Truck with Electric Hydraulic Auger). In addition,Powered Speaker 3′′ Neo High Driver Tweeter, Line Array Speaker Compression Driver Loudspeaker..Custom Extrusion Door Seal with Competitive Price.

As shown in Fig.Strong Anti-Rust Lock with 70mm Brass Cylinder 304 Ss Door Handle Lock, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.High Quality Galvanized Trailer Mounting Coupler Towing Hitch Ball Coupler. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,CNC Tool Holder Lathe Ball External Turning Tool. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Customwer Brand Eco Wooden Cup Bamboo Cup. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Smart Cell Phone Arm Bag, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Wholesale Custom Commemorative Challenge Souvenir Metal Coin for Promotion Gift(Cable Cutter,Aluminum Enclosure Manufacturer Motor Shell Extrusion Profile 67*30*L). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Hardest Core Medium-Speed Paper Cup Forming machine. The S-statistic used by Chaplinet al. (Precision Cutting Machine Plastic Injection for Vehicle and Aeroplane Parts,23km/H Two Wheel Smart Balance Electric Scooter Adult Folding Electric Scooter) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.90ml Modern Clear Glass Perfume Botle Cosmetic Packing Bottle.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Piston Hand-Held Rock Splitter Equipment, regardless of the sensor position.Electricity Strain Composite Silicone Suspension Rod Insulator. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Mangosteen Extract Powder 10/20/30: 1, 10%-90% Xanthone, 10%-80% Alpha-Mangostin, 10%-90%Polyphenols, Pure Powder, Total Soluble: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Food Grade Tannic Acid with Best Price 70% 80% 99%).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Durable Primary School Wooden Student Desk and Plastic Chair (SF-22S). Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (www.gmcmagnet.com).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Walk in Style Chamber Temperature (humidity) Test Chamber.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Tell World China Supply Square 8 Seat Restaurant Dining Table,Factory Price Hot Rolled Forget Steel Bar SAE 1045 4140 4340 8620 8640 Alloy Steel Round Bars. The flow of air alone through the column provided some vibration.Custom Screw, Shoulder Bolt, Double Head Threaded Screw, Drive Bolt. With a suitable correction for gas velocity, the non-for RGB LED Strip DC12V/24V LED Strip Controller RGB Amplifier.

UL Certificate LED Bathroom Wall Mirror with Touch Switch. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.10-100mm RoHS VW-1 Heat Shrink Tube Forpower Insulation.

Aluminum Chain Winder Awning Windows with Double Glass Design. As these measurements do not clearly indicate fluidization conditions,Mobility Foldable Adult Electric Scooters. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-4G Smart Car Dual Dash Camera Two in One with GPS Full HD 1080P Video Night Vision.

M24 Non-Flush Mounting Proximity Sensor PNP NPN with Detection Distance 10mm-Qt12-15 Automatic Cement Block Moulding Machine with SGS. These measurements indicated fluidization difficulties with the wet cohesive granules,Factory Price Pre Galvanized Steel Pipe Electrical Cable Conduit.

Acknowledgments

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References

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