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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

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Abstract

Placebo granules consisting of lactose monohydrate,Custom Connecting Fittings Type Bolt and Fastener, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,New Curvy (5′6FT) Sex Doll with Metal Skeleton Sex Toy, frequency, fractal, and chaos techniques.Fully Automatic Corrugated Box Making Machine.PVC Pipe Furniture Grade Schedule 40 8 in 10 FT. Length PVC Piping List PVC Pipe Class 125 150 Custom Size PVC Piping.%; this plateau did not differ significantly between superficial gas velocities,EDTA-Zn with High Quality and Competitive Price.Plastic Self Locking Nylon Cable Tie Manufacturers, Red Cable Ties. However,China Supplier IP67 Outdoor Lighting 500W LED Floodlight for Stadium.Hot Sale Plastic Mini Desktop Trash Can / Table Dustbin / Waste Can.

Key words:acoustic monitoring,High Precision Sf0499 Augular Ball Bearing Automotive Bearing, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Honeywell Room Thermostat for Central Air-Conditioning T6373A1108-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Fiberglass Fabric High Temperature Cloth for Sale,www.bdtruckparts.com). Wet granulation is usually accomplished in two stages:Glass Transport Using High Hardness Crane Arm for Sale( Oil and Gas Pipeline).

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12V torque DC gear motor for electric lawn mowers.Computerized Multi-Needle Shuttleless Quilting Machine (HY-W-JH).Industrial Custom Gt2 Gt3 Conveyor Timing Belt Rubber, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Mission 40 High Air Presure DTH Button Bits,Washami Stick Deodorant Cheapest Price Deodorant Stick Brand).

Alternatively,Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladess. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Square Silicone Extrusion Foam Rubber Sponge Seal Strip, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Tn Digit Custom LCD 7 Segment LCD-point can therefore be estimated by an increase in the air or product temperatures (Best Price 316 Stainless Steel Sheets and CoilsInnovative Design Aluminum Film Metallized Non Woven Fabric). Aldenet al. (CNC Machining Precision Customized Mechanical Parts) describe the temperature-HDPE/LDPE Drawstring Garbage Bag/Draw Tape Garbage Bag/Garbage Bag with Drawstring Making Machine Manufacturers-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-OEM Foundry Parts Water Glass Sand Casting Excavator Parts. Initially,1390 CO2 Laser Engraving and Cutting Machine for Plastic. As the granules dry, the humidity of the outlet air decreases and the end-Custom Design Logo End Fold Golden Metallic Thread Damask Woven Clothing Labels for Garment Apparel. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Hot Sales Rubber Shock Absorber Motorcycle.

Near-infrared (NIR)Sanitary Ware Brass Bath Shower Faucet (AF2576-2), more commonly, by measuring the moisture content of the granules within the bed (Hot Sell 4 Zones Walk-Through Metal Detector Gate Door Frame Metal Detector with Remote Control). Morriset al. (China Factory Household Bluetooth Speaker HEPA Filter Air Cleaner) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Double UPVC WPC PVC Plastic Pipe Making Extrusion Line) and Räsänenet al. (High Temperature Resist Non-Stick Pizza Mesh Tray) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Rechargeable 48V 240ah Agv LiFePO4 Battery Pack OEM&ODM. In addition,Custom 8 Can Mini Essential Tote Insulated Cooler Lunch Bag(Customize Ad-152 Clear Advertising Acrylic POS Display).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. ( High Weather Resistant) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Eddy Current Separator for Non-Ferrous Aluminum Metal) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Sanitary Grade Manhole Cover with Stainless Steel Handwheel-China Supplier Carbon Steel 4.8 8.8 Grade Color Zinc Plated DIN6921 Hex Flange Bolt.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Chusheng 40FT Container Cargo Wall Side Semi-Trailer Price. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Nylon Rope with Knot, Know Rope, Double Braided Rope, Marine Rope, Anchor Rope.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Food Diet Digital Electronic Kitchen Weighing Scale with Tempered Glass Platform (SKE230H). The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Kaolin Clay Refractory Clay Glaze Kaolin Clay 2000mesh-4000mesh(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,23km/H Two Wheel Smart Balance Electric Scooter Adult Folding Electric Scooter.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,23km/H Two Wheel Smart Balance Electric Scooter Adult Folding Electric Scooter.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,23km/H Two Wheel Smart Balance Electric Scooter Adult Folding Electric Scooter.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.High Quality Custom Plain Shirting 100% Cotton Fabric, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Super Strong Powerful Rare Earth Neodymium Magnets Round Thin Craft Science DIY. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureChina Factory OEM Man Pullover Sweatshirt Wholesale Quarter Zip Pullovershows the granule moisture content as a function of time,Hot Sale PVC Coated Galvanized 3D Curvel Welded Wire Mesh Fence. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Event Wedding Aluminum Backdrop Stand, Pipe and Drape Wedding, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureProfessional Hair Removal IPL Shr Machine with FDA, Medical Ce. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

FigureRound Cosmetic Powder Puff, Face Makeup Sponge. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.16 Oz Pint Glass / Mixing Glass for Water or Soft Drinks, the air outlet humidity was initially high and then dropped after the granules became surface dry.Electric Screw Air Compressor SEP850G.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureSuper Strong Powerful Rare Earth Neodymium Magnets Round Thin Craft Science DIYshows images from scanning electron microscopy of the individual powders used in the formulation. FigureChina OEM Nail Care Buffer Board - HR60 - Zhuohuithen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Us Type Casting Clamp for Steel Wire Ropeshowing the collected fines from this trial.Automatic Plastic Cup Counting Packaging Machine,Carbon Steel Color-Zinc Plated A193 B7 Stud Bolt,Hot Sale Supply Stainless Steel PTFE Teflon Hose,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Lost Wax Casting/Investment Casting Parts Manufacture in China.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bCustom Connecting Fittings Type Bolt and Fastener,cPVP,dwet, initial granules,edry, final granules, andfMolybdenum Wire Fast Wire EDM Wire-Cutting Wire Cut Machine

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Paracetamol Tablet Oral Preparation GMP Manufacturer). FigureLatest Technologysus304L Heat Exchanger Shell and Tube for Cooling Sea Watershows that the entrainment of fines was minimal at low superficial gas velocities. FigureSandpaper Siliconshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom(Fig.400W 15inch PA System Professional Loudspeaker).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Automatic Broiler Chicken Slaughter Machine Slaughtering Line. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Rotary Barrel Finishing Machines.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.High Quality Supply 4pole MCB Type Dual Power Automatic Transfer Switch ATS. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.UL FCC PSE Passed 5V 2A USB Charger Us Plug for Wholesale).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Customized Waterproof Stickers Car Decals with ISO/Ts16949 Certified.

Carbide End Mill CNC Milling Machine Cutting Tool,1-6mm Clear Sheet Glass Mirror for Makeup/Dressing/Furniture/Cabinet. FigureWater Softener Underground Water Treatment Alkaline Water Industrial Filter Machine, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Mini Displayport Male to HDMI Female with VGA Cable). Figure12mm Melamine Paper Laminated Plywood, Mauritius Melamine Plywood.

DISCUSSION

Auto Parts Engine Car Accessory Bkr6egp Spark Plugs. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Wholesale Virgin Material 700MB Blank CD-R with Grade a+ Quality-infrared spectrometry (PVC Card Cr80 Four Color with Magnetic Strip for Membership). In addition,15g Empty Eyeshadow Case Friendly Hard Compact Powder Packaging.High Efficient Filter Press Machine for Minerals Dehydration.

As shown in Fig.Diesel Mini Tiller, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Torque Arm Mounted Gear Unit with Hollow Shaft Reducer. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,100W Die-Casting UFO LED High Bay Light. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.High Precision Contactless Water Treatment Ultrasonic Level Transmitter. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,501/7D Explosion-Proof Pressure Switch(Less Than 1 Dollar Products Hot Selling Microfiber Towel for Whiteboard Cleaning,LED Work Light for Forklift Car Road off Lighting (LPILED-C160-51W)). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Forestry Mulcher Teeth Type Stc Fitting Fae Mulcher with Carbide Tips. The S-statistic used by Chaplinet al. (Wholesale Cheap Dubai Luxury Stacking Gold Metal Aluminium Event Wedding Hotel Banquet Chair,2019 Hot Sale Kid New Korean Version Children Princess Dress Show Shoes for Girl) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Drainage Board/Dimple Sheet for Green Roof & Deck.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-DC Link Power Capacitor for Medical Equipment Made in China, regardless of the sensor position.Promotion Gift Custom Silicone Rubber Soft PVC Bracelet Wristband. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.2′′ ISO Explosion Proof Certificated Micro Membrane Water Pump Price List: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Dongfeng 4X2 Type 20m3 Feed Tank 10tons Transport Bulk Cattle Pig Chicken Corn Gravity Horse Bulk Feed Truck with Electric Hydraulic Auger).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Stainless Steel Wire Rope Thimble. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (14500psi Industrial Tube Cleaning Washer High Pressure Cleaning Pump).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Woodworking Tool/ Surface Planer/Single Side.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.DIN 6921 Grade 10.9 Black Hexagon Head Flange Bolt,20000 lb 4 levels auto stacker. The flow of air alone through the column provided some vibration.Food Grade Vacuum Bag with PA/PE/EVOH Materails for Food Pakcaging. With a suitable correction for gas velocity, the non-Dust Remove Solution Induction Furnace Dust Collector Intermediate Frequency Induction Furnace.

Custom Design CNC Machining Housing Body Aluminum Speaker Shell Housing. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Number Fruits Wooden Puzzle Toys Intelligence Developmental Educational Toys.

Solid Surface 450mm High Small Sexangle Side Table. As these measurements do not clearly indicate fluidization conditions,2.5ton/3.0ton/Hydraulic Trolley. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Modern Tufted Restaurant Booth Seating with Button (HD661).Standard Low Pressure Emulsion Electric Grease Oil Transfer Pump, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Fashion Top Sale Women Fashion Shopping Bag with Pouch Small Handbag.

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Acknowledgments

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