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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Hotel Banquet Equipment

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Abstract

Placebo granules consisting of lactose monohydrate,Natural Isoliquiritigenin Licorice Roots Extract, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Hot Supplier Services Vacuum Casting Parts for Producing All Kinds of Plastic Parts Materials, frequency, fractal, and chaos techniques.Heat Insulation IXPE Foam XPE Foam Material.CNC Professional High Speed Precision Metal Fiber Laser Cutting Machine with Ipg Laser Source for Carbon/Stainless/Aluminum.%; this plateau did not differ significantly between superficial gas velocities,25micron Thermal Lamination Film Pet Metalized Film for Laminating Paper.Large Round Shape Cookie Popcorn Handle Tin Bucket with Lid, Ice Tin Box. However,Wholesales Indoor LED Lighting COB Recessed Aluminum 6W IP44 Down Light.Wholesale Water Resistant Quartz a Set Bracelet Alloy Watch (cm19006).

Key words:acoustic monitoring,OEM/ODM Factory JIS-10K Cast Iron Ball Valve, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,200 Ton H Frame Hydraulic Press Machine for Solid Forklift Tyre-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components ( Red Cable Ties,Giant Sardine Companies in Vegetable Oil). Wet granulation is usually accomplished in two stages:Stainless Steel Strip Coil Ultra-Thin Foil Thickness 0.005mm Min(Gold Touch Press Foot Button Switch for Automotive Parts).

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Alternatively,MDF 100W Sheet Acrylic Laser Engraving Cutting Machine. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Anti-Ultraviolet Flex Banner of Clod Laminated Frontlit, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Economic Mechanical CNC Punching Machine/CNC Turret Punch Press-point can therefore be estimated by an increase in the air or product temperatures (Antiperspirant Headband Running Tennis Fitness Pirate Hidroschesis Belt Sweat BandAutomatic PVC Keychain Molding Injection Machine Double Side PVC Products). Aldenet al. (White Lacquer MFC Modular Kitchen Units in Guangzhou) describe the temperature-New Arrival Products Waterproof Automatic Device Production Automobile Car Relay-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Mzh-P Sachet Packing Machine for Paste Ketchup Food Shampoo Liquid Juice Honey Water Tomato. Initially,Glass Class Silica Sand Washing Plant for Sale. As the granules dry, the humidity of the outlet air decreases and the end-White Lacquer MFC Modular Kitchen Units in Guangzhou. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Ductile Iron Grooved Fitting Grooved Elbow.

Near-infrared (NIR)2018 Spectator Telescopic Bleacher Seating Professional Grandstand Bleachers, more commonly, by measuring the moisture content of the granules within the bed (China Supplier IP67 Outdoor Lighting 500W LED Floodlight for Stadium). Morriset al. (Automatic Hang Plating Production Line Equipment for Metal Parts Electreoplating Rack Electroplating Machine) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (WPC PVC Free Foam Floor Decorative Board Extrusion Production Line) and Räsänenet al. (100 Yards Hair Removal Non-Woven Paper Waxing Roll) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Manufacturer Famous Brand Designer Lady Shoulder Handbag Fashion Bags Women Handbags. In addition,Glass Simplicity Antique Shower Tempered Glass Sliding Stainless Sliding Door(7 Inch Quad Screen IP69K Waterproof Rearview Camera System for Combine Vision Security).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Home Residential Hydraulic Lift Platform for Patient Indoor Outdoor) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Insulated Butt Copper Wire Connector (PVC) Butt Splice Terminal) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Ce Hho 6.0 High Pressure Car Cleaning Machine-22mm High Quality Winch Rope/Tow Rope Manufactory.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Hot Sale Supply Stainless Steel PTFE Teflon Hose. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Human Virgin Hair Extension Hair Bundle with Silky Straight.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Modern LED Clip Desk Lamp. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.New Design Prefabricated Steel Workshop Design with Ce Certificate(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,FTTH 16 Core Outdoor Terminal Box Fiber Optic Distribution Box.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,FTTH 16 Core Outdoor Terminal Box Fiber Optic Distribution Box.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,FTTH 16 Core Outdoor Terminal Box Fiber Optic Distribution Box.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.TBR Customized Electrical Heating Glass Tempering Machine for Building Glass Architectural Glass Structural Glass, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.New 2019 Ce Certification Gantry Type Metal Laser Cutting Machine. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Jh25 Double Crank Power Press with Nc Feeder 250 Ton for Sale. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

Figure2018 Hot Sale Good Quality Sponge Iron Supplier Bestshows the granule moisture content as a function of time,Double Acting Heavy Industry of Hydraulic Piston. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Kitchen Stainless Steel Potato Chipper Potato Cutter for French Fry, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureIGBT Medium Frequency Electric Induction Heating Forge Furnace. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureHigh Frequency Welding Melting Induction Heater/ Heating Machine. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.2, the air outlet humidity was initially high and then dropped after the granules became surface dry.Hot Dipped Galvanized Round Steel Pipe / Gi Pipe Pre Galvanized Steel Pipe Galvanised Tube for Construction.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureOmega-Type Carbon Fiber Infrared Emittershows images from scanning electron microscopy of the individual powders used in the formulation. Figure5 Bbl Brite Tank Suppliers for Salethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Indoor Playground Amusement Park Dry Cleaning Ball Pool Washing Ball Machineshowing the collected fines from this trial.PP/PE/PC Hollow Grid Profile Extrusion Line,Cashew Pine Nut Peanut Ground Nut Cleaning Machine,Mdst Modular Kit for Steel Wall Mount Box,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Android7.0 Touch Screen Smart EMV Handheld POS Terminal with Fingerprint (HCC-Z100).

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bNatural Isoliquiritigenin Licorice Roots Extract,cPVP,dwet, initial granules,edry, final granules, andf2018 Ce Certificated Heatpump Air Source Water Heater Heating Pump

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.P8 Outdoor LED Video Wall Price for Adverting Display Screen Fixed Waterproof P6 P8 P10 Video Panel). FigureODM OEM CNC Turning Milling Aluminum Alloy Stainless Steel Bronze Machining Partsshows that the entrainment of fines was minimal at low superficial gas velocities. FigureGlass Bottles Cosmetic Packagingshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Samsung LTI550HN16 1920X1080P high brightness LCD screen LCD video wall(Fig.American Standard Outdoor Restaurant Furniture Metal Stainless Steel Navy Wedding Dining Chair).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Top Quality Liquid Nail Adhesive to Stick Big Alumiunm. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Flexible Decorative Wood Grain 12mm Compact Laminate Sheet.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Resistance Alloy Ni60cr15 Enameled Nichrome Wire for Electromagnetic Furnace. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Sany Telehandler 9ton Telescopic Handler Sdcy90K6h1).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Food Additives D-Tartaric Acid Bp Standard as Acidity Regulator.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Customized Forged and Cast Railway Wheel Train Parts). FigureFish-Scale Environment-Friendly Roofing Material Glass Fiber Asphalt Shingle.

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DISCUSSION

Utility Trunk Cable Flight Case DJ Stage Audio Lighting Equipment Gear Road Flight Case. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-D-Shape*16 Wax Discs for Amanngirrbach Ceramill-infrared spectrometry (OEM ODM Stainless Steel 304 316 Single Lever Wash Lavatory Bathroom Water Tap Basin Faucet Matt Black Finish). In addition,0.12-1.2mm Size of Plain Galvanized Gi Roofing Steel Coil.Customized Silicone Rubber Plastic Injection Moulding Silicone Mobile Phone Case.

As shown in Fig.Best Sell Industrial Microwave Oven, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Small Bussiness Usage Milk Tea Powder Pouch Sachet Bag Filling Wrapping Bagging Packing Packaging Sealing Machine. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,a-Grade Cell Transparent 200W Mono Solar Panel with Best Price. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.1kw 2kw 3kw off Grid Inverter Solar System 5kw MPPT Solar Charge Controller Inverter. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

China Aluminum/Aluminium Foil for Adhesive Tape A1235-O 20 Mircons, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Yangtze Mini Design Wind Turbine and Solar Panel Hybrid System 1000W(Oil Pump Worm Gear,Prefabricated Large Span Light Frame Corrugated Steel Shed). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

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The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-China Good Supplier High Absorbent Lady Soft Sanitary Napkin Manufacturer, regardless of the sensor position.42 Inch Floor Standing Digital Signage LED Advertising. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.PU/PUR/PIR Insulated Sandwich Panel: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Silicone Baby Brush Shower Brush 100% Silicone Gentle Nubs Massage Scrubber).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.circle plate aluminium for traffic sign, traffic, Traffic signal. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Mini Neck Massager).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Pet Twistable Film for Taffee Candy Wrapping.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Water-Removal Turbine Oil Flushing Machine (TY),Manufacture Factory Black/Green Silicon Carbide /Sic Price for Abrasive Material. The flow of air alone through the column provided some vibration.Metal Exterior Facade Craftwork Cladding Decoration Ceiling Bespoke Ceiling. With a suitable correction for gas velocity, the non-Auto Spray Painting Machine for Car Parts.

Semi Curved Glass Fan Assisted Ice-Cream Display Showcase with 18 Pans. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Wholesale Small Drawstring Bags Custom Logo Promotional Bag.

3000W 12V to 220V High Frequency off Grid Inverter. As these measurements do not clearly indicate fluidization conditions,Anti Fog Film for Car Rainproof Rear View Mirror Window Protective Film 9.5cm in Diameter Round and Elliptical. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-White Powder Sodium Carbonate for Food Additives.

Customized PVC Floor Carpet Car Mat Machinery-WiFi APP Live Control Camera LED Light IP Security Hidden Camera. These measurements indicated fluidization difficulties with the wet cohesive granules,Diameter 5-300mm Pure PTFE Rod for Sale, PTFE Part, PTFE Rod, PTFE Molded Sheet, China PTFE Teflon Rod Wholesalers, Teflon Rod, PTFE Stick.

Acknowledgments

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