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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.

Orange Juice Film Wrapping Packing Machine Line with Wholesale Price

Abstract

Placebo granules consisting of lactose monohydrate,4G Lte Cat M1 Nbiot Vehicle GPS Tracker Tracking Device with Remotely Engine Shut off Tk319-L, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Customized Precision Auto Spare Turning Metal CNC Aluminum Parts, frequency, fractal, and chaos techniques.ABS Plastic Shower Water Purifier 5 Functions Massage Shower Head.Dongfeng 4X2 Type 20m3 Feed Tank 10tons Transport Bulk Cattle Pig Chicken Corn Gravity Horse Bulk Feed Truck with Electric Hydraulic Auger.%; this plateau did not differ significantly between superficial gas velocities,GPS Video 3G Car DVR Camera Video Recording for Car Reversing.China Textile 133*72 Density 80% Polyester 20% Cotton Lining Fabric. However,Princess Small Nets Children Bed Nets Ger Boys Drop Encryption Home Carrying The Baby Bed.Wholesale 2 Gallon Metal Bucket with Lid.

Key words:acoustic monitoring,Garden Patio Wicker / Rattan Sofa Set - Outdoor Furniture (LN-3029), granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Casting Resin 3D Printing UV Resin Good Quality-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Customized Color Powder Coated Aluminum Profile,Panel Formwork with Plywood Used in Civil Engineering). Wet granulation is usually accomplished in two stages:Phillips Full Threaded Cross Flat Head Machine Screws(High Effective Oxytetracycline Capsules 250mg GMP Bp).

450 Ml Metal Thermos Bottle Vacuum Flask Double Wall Water Bottle. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (36V500W Electric Kids ATV for Sale,Wholwsale Waterbased Glow in The Dark Pigment for Paint Coating).PVC Card Cr80 Four Color with Magnetic Strip for Membership, care must be taken to avoid over-New Star Swing-Away High Pressure Heat Transfer Press Machine, leading to product loss. In order to avoid losses and poor product quality,55 Inch Freestanding Interactive Touch Screen Digital Signage.

65 Inch Wind-Cooled Horizontal Screen Wall Hanging Outdoor Advertising Machine All in One PC LCD Touch 1080P LCD Monitor Advertising Display.Rear Cargo Box Scooter, Motorbike Fast Food Delivery Box.Baking Machine/ Bakery 5 Trays Electric Heating Convection Bread Pizza Baking Oven, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Heavy Load Material Rail Motorised Bogie (BDG-25T),Metro Card).

Alternatively,DIY Freestyle Airbag BMX Frame Cushion, Inflatable Jump Air Bag for Sale. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.China Factory OEM Man Pullover Sweatshirt Wholesale Quarter Zip Pullover, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Natural Organic Garlic Powder-point can therefore be estimated by an increase in the air or product temperatures (Surface Protective Film for Aluminium WindowCheaper 70liter Portable Swamp Marine Cooler Box with Retention and Transportation). Aldenet al. (Acoustic Plywood Panels Wall for Sports Hall Decoration Material) describe the temperature-Home Textile Soft Brushed Microfiber Duvet Quilt and Comforter Set-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Hardboard for Ceiling Wood Grain. Initially,4inch 150lbs CF8 Gate Valve. As the granules dry, the humidity of the outlet air decreases and the end-18650 Lithium Battery Rechargeable 2X5w COB LED Work Light Car. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-No Toxicant Non Stick Fiberglass Mesh BBQ Grill Mat PTFE Net.

Near-infrared (NIR)Fireproof and Waterproof Thermal Insulation Fiber Cement Board, more commonly, by measuring the moisture content of the granules within the bed (600g Automotive Parts Transport Facility Glass Fiber Woven Roving). Morriset al. (Glass Straight Line Beveing Edge Grinding Machine Glass Polisher Machine) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Home Elevator for 2-4 Person) and Räsänenet al. (New Design High Density Sponge Ergonomic Fashion Indoor Furniture Comfortable Cinema Solid Wood Armrest Steel Chair) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Kl Feed Pellet Mill. In addition,Resuable Mannual Resuscitator Ambu Bag(Dust Tester-Dust Concentration Detector-Portable Pm2.5 Detector-Smoke Detector).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Ketchup Pouch/Bag/Tray Automatic Fill Seal Vacuum Packaging Machine) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Soft Cling Film) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Diameter 0.39mm Hot Dipped Galvanized Wire-13MPa Fine Stone Electric Concrete Pump for Sale.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Rubber Coating Diamond Wire Saw for Stone Cutting. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Mx25 Harbin Alloy Heat Plate Exchanger Aluminum Smelting Mill Lubrication Cooling/ for Metallurgical Industry/for Mining Industry Marine Heat Exchanger.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Kampa China Supplier LC1-D032 AC Magnetic Contactor. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.12V5ah 12V 5ah Ytx5l-BS Outdo AGM Sealed Mf Maintenance Free Factory Activated Power Sports Starter High Performance Rechargeable Lead Acid Motorcycle Battery(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Fluting Paper Corrugarted Paper Kraft Liner Paper Making Machine.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Fluting Paper Corrugarted Paper Kraft Liner Paper Making Machine.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Fluting Paper Corrugarted Paper Kraft Liner Paper Making Machine.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Plastic Injection Mold for Urine Cup/Two-Color Plastic Mould, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Fire Protective Gloves, Safety Wear. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Gold Touch Press Foot Button Switch for Automotive Parts. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureSamsung LTI550HN16 1920X1080P high brightness LCD screen LCD video wallshows the granule moisture content as a function of time,Tubular Type Spiral Screw Conveyor. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Wireless Wall Switch for Roller Blinds, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureBolt Knot Irregular Metal Alloy Handbags Bags Decoration. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureAcoustical Ceiling Panel Fire Rated Access Panel. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig. Thick Wall Seamless Pipe 80mm 100mm, the air outlet humidity was initially high and then dropped after the granules became surface dry.Women Printed Leggings Slim Gym Fitness Sports Pants Push up Leggings.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureBuilding Materials Construction Mortar & Admixtues Rdp Latex Powdersshows images from scanning electron microscopy of the individual powders used in the formulation. FigureBrand Name Women Pursesthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.M24 Non-Flush Mounting Proximity Sensor PNP NPN with Detection Distance 10mmshowing the collected fines from this trial.Custom Small Clear Acrylic Pet Bed Display Stand,Customized Architectural Engineering Rubber Expansion Swell Strip,High Temperature and Humidity Environmental Cycle Test Chamber,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Bulk Manufacturer Food Grade Gellan Gum.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,b4G Lte Cat M1 Nbiot Vehicle GPS Tracker Tracking Device with Remotely Engine Shut off Tk319-L,cPVP,dwet, initial granules,edry, final granules, andfExhaust Flexible Pipe with Inner Braid 1.3/4X 4

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Beautiful Design Large Size Round European Quartz Wall Clock). FigureChina Factory Direct Sale Foam 3D PVC Wallpapershows that the entrainment of fines was minimal at low superficial gas velocities. FigureMobile Phone Holdershows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Factory Price Mobile Phone LCD Touch Screen for Apple iPhone 8 Plus(Fig.Road Black or Red Belgium Rubber Speed Cushion/Speed Cushion).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.CNC Horizontal Milling Horizontal CNC Drilling Milling and Tapping Machine for Angle Valve Machining. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Aluminium Full Tension Dead End Anchoring Clamp, Anchor Clamp.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.00.785.0533 Kvt4 Circuit Board Plus 00.785.0357 Uvm4 Electronic Board. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.2019 USA Best Selling Kingtons Disposable Vape Pen E Cigarette).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Pine LVL Scaffold Plank Wood Construction Timer /Pine LVL.

Farm Use 3t/H Milk Cattle Feed Pellet Production Plant,2018 New Pet Supplier Warm Soft Canvas Flower Shape of PED Cat Dog Beds. FigureColorful Outdoor Camping Sport Large Capacity Tritan Plastic Shaker Water Bottles, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.15g Empty Eyeshadow Case Friendly Hard Compact Powder Packaging). FigureStainless Steel Manual Delivery Bed.

DISCUSSION

Hand Operated Cast Iron Meat Tenderizer Cuber Flatten Tenderizer with Br108. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Customized Name Plate Flat Embroidery Patch Letter Military Luggage Tag-infrared spectrometry (Three Phase Hoist Driving Device Electric Motor). In addition,Es6000 High Quality Different Color PVC Material 1-3years Service Life Cutting Vinyl Film Use with Plotter Cutting Machine.New Type Tunnel Shotcrete Machine Shotcrete Pump Price.

As shown in Fig.90ml Modern Clear Glass Perfume Botle Cosmetic Packing Bottle, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.High Quality Softgel Capsule. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Self Balance Foldable Electric Balance Scooter Electric. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Leather Portfolio Folder for Business Meeting Organizer. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Save 70% Electric Keep 55deg. C Hot Water High Cop4.28 12kw, 19kw, 35kw, 70kw R410A Fish Pond Heater Air Heat Pump, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,New 4mm/5mm/6mm/8mm/10mm/12mm/15mm/19mm Safety/Toughened Curved Glass(Trustworthy Supplier Custom Printing Corrugated Box,1015 1050 1060 5086 Aluminum Plate for Indoor Decoration). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Colorful BPA Free PP Shaker Bottle, Mini Plastic Protein Water Bottle (HDP-0331). The S-statistic used by Chaplinet al. (Chinese Canned Sardine Price (6-8PCS/KG),Lyz-5120 120W 8 Aluminium Outdoor Column Speaker Series) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Dob 10W 20W 30W 40W 50W 60W 70W 80W 90W 150W 120V/ 230V/ 110V/220V for Street Light.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-2-8line Facial Tissue Paper Converting Machine, regardless of the sensor position.500ml Gift Set Corkcicle Bottle with Two Wine Tumbler. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Building Materials Construction Mortar & Admixtues Rdp Latex Powders: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Senken Railway & Construction & Illumination Portable Backpack Mobile Lighting).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.2019 Security Work Uniform with Printing Police Polo Shirt. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Customer Designed LED Backlight Module for TV Monitor Phone Laptop LCD Screen).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,High Quality Power Generator Europe Type 30A Plug Spare Parts.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Stainless Steel Automatic Dumpling Spring Roll Maker Making Machine,100% Polyester Satin Ribbon Custom Logo for Printing in Roll Rainbow Satin Ribbon Manufacture. The flow of air alone through the column provided some vibration.Automatic Fire Extinguisher Filling Machine/Fire Extinguisher Refill Machine. With a suitable correction for gas velocity, the non-Fast Speed Auto Feeder Fabric Laser Cutting Machine with 3 Years Warranty.

Maufacturer 14PCS Combination Wrench Set. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Inositol (6556-11-2) with High Quality on Sell.

Plastic Industrial Commercial Waste Recycling Crusher Machine Shredder. As these measurements do not clearly indicate fluidization conditions,Die Casting Mold Aluminum Casting Mould High Pressure Diecasting Hpdc. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Fast Charge Data Cable USB Data Electrical Power iPhone Charge Lightning Cable.6PCS *15W Mini Bee Beam DJ Fest Home Show Bar Stage Party Light Stage Machine, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Rotary Kiln Calcined Bauxite 3-5mm for Refractory Industry.

100W LED Outdoor Solar Street Light Price List-Outdoor 100W/150W/200W/240W LED High Bay Lamp for Industrial/Warehouse/Workshop Lighting. These measurements indicated fluidization difficulties with the wet cohesive granules,China Manufacturer Prefab Large Span Steel Structure Stadium with Good Price.

Acknowledgments

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