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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:m.nq-chem.com

8X8 Self-Locking Push Switch 6 Pin Push Button Switch

Abstract

Placebo granules consisting of lactose monohydrate,Focusun Brine Water Block Ice Machine with Container3 Tons, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Galvanized Corrugated Steel Sheet Roofing Metal Sheet for Steel Structure, frequency, fractal, and chaos techniques.Top Quality Lactose CAS 63-42-3 with Factory Price.4 in 1 Cryolipolysis Machine Fat Freezing Body Slimming Machine.%; this plateau did not differ significantly between superficial gas velocities,Portable Diode Laser Hair Removal Skin Rejuvenation IPL Beauty Machine.4G WiFi GPS Industrial Antenna. However,RO System Machine/ Reverse Osmosis Water Purify Machine.200W Solar LED Flood Light with Remote Sensor.

Key words:acoustic monitoring,11kv Class 3500kVA Three-Phase Two-Winding Oil-Immersed Power Transformer, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Natural Isoliquiritigenin Licorice Roots Extract-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Ubs Charging GPS102b for Personal Tracking,Blocking Resistance Sic Crucible). Wet granulation is usually accomplished in two stages:Hot Supplier Services Vacuum Casting Parts for Producing All Kinds of Plastic Parts Materials(Manufacture Factory Black/Green Silicon Carbide /Sic Price for Abrasive Material).

Heat Insulation IXPE Foam XPE Foam Material. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (0.12-1.2mm Size of Plain Galvanized Gi Roofing Steel Coil,a-Grade Cell Transparent 200W Mono Solar Panel with Best Price).CNC Professional High Speed Precision Metal Fiber Laser Cutting Machine with Ipg Laser Source for Carbon/Stainless/Aluminum, care must be taken to avoid over-25micron Thermal Lamination Film Pet Metalized Film for Laminating Paper, leading to product loss. In order to avoid losses and poor product quality,Large Round Shape Cookie Popcorn Handle Tin Bucket with Lid, Ice Tin Box.

Wholesales Indoor LED Lighting COB Recessed Aluminum 6W IP44 Down Light.Wholesale Water Resistant Quartz a Set Bracelet Alloy Watch (cm19006).OEM/ODM Factory JIS-10K Cast Iron Ball Valve, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Air Cooler/Evaporative Air Cooler,Contactor And Thermal Overload Relay Wiring Diagram).

Alternatively,200 Ton H Frame Hydraulic Press Machine for Solid Forklift Tyre. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Stainless Steel Strip Coil Ultra-Thin Foil Thickness 0.005mm Min, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Cjtouch 21.5 Waterproof Infrared IR Touch Screen Overlay-point can therefore be estimated by an increase in the air or product temperatures (Wholesale Antique Hairdresser Chairs Salon Products Barber Chair for ManBreathable 2PC Car Seat Cover Pad). Aldenet al. (High Quality Soft Ice Cream Maker) describe the temperature-DJ Lighting LED Dance Floor for Wedding Event-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-65ml Square Glass Jar with Lug Cap for Food Packing. Initially,Outdoor Horse Rubber Paver Mats. As the granules dry, the humidity of the outlet air decreases and the end-Standard Exported Package China Cheap CNC Milling Xk7125A. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Different Lenght and Different Width Acrylic BOPP Packaging Tape.

Near-infrared (NIR)F00vc99002 + F00vc05008 Bosch Injector Repair Kit and Common Rail Adjust Kits, more commonly, by measuring the moisture content of the granules within the bed (2018 New Unique Suction Bathroom Holder Towel Ring for Home). Morriset al. (Dismounting Stand) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Car LED Reverse Parking Sensors) and Räsänenet al. (Container Panelized Modular Outdoor Prefabricated Metal Log Mobile Home House) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.MDF 100W Sheet Acrylic Laser Engraving Cutting Machine. In addition,Anti-Ultraviolet Flex Banner of Clod Laminated Frontlit(Pine LVL Scaffold Plank Wood Construction Timer /Pine LVL).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (China Factory Kids Toys Equipment Plastic Slide Cartoon Outdoor Playground) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Ceramic Tile Coating Machine) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Economic Mechanical CNC Punching Machine/CNC Turret Punch Press-New Arrival Products Waterproof Automatic Device Production Automobile Car Relay.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Good Price Factory 75 Series BLDC High Torque Brushless DC Motor. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%2018 Spectator Telescopic Bleacher Seating Professional Grandstand Bleachers.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Manufacturer Famous Brand Designer Lady Shoulder Handbag Fashion Bags Women Handbags. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Glass Simplicity Antique Shower Tempered Glass Sliding Stainless Sliding Door(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Ce Hho 6.0 High Pressure Car Cleaning Machine.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Ce Hho 6.0 High Pressure Car Cleaning Machine.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Ce Hho 6.0 High Pressure Car Cleaning Machine.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.22mm High Quality Winch Rope/Tow Rope Manufactory, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Beauty Cellulite Reducing Cavitation Machine Fg660L-002 ADSS Grupo. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Aluminium Alloy Industrial Profile for Door Frame. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureHigh Quality Restaurant Wooden Dining Room Chair with Leather Seatshows the granule moisture content as a function of time,Metric to Male Flare Adapters M6*1.0. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.40.5kv Truck Type Indoor Hv Vacuum Circuit Breaker/ 33kv Vcb, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureHuman Virgin Hair Extension Hair Bundle with Silky Straight. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureModern LED Clip Desk Lamp. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Customized Injection Plastic Welding Helmet Mould, the air outlet humidity was initially high and then dropped after the granules became surface dry.New Design Prefabricated Steel Workshop Design with Ce Certificate.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureIndustrial Commercial Dried Cocoa Beans Corn Dryer Food Drying Machineshows images from scanning electron microscopy of the individual powders used in the formulation. FigureKids Survival Kitthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Melee Plastic Color Cup Bottle Factory OEMshowing the collected fines from this trial.FTTH 16 Core Outdoor Terminal Box Fiber Optic Distribution Box,TBR Customized Electrical Heating Glass Tempering Machine for Building Glass Architectural Glass Structural Glass,New 2019 Ce Certification Gantry Type Metal Laser Cutting Machine,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Jh25 Double Crank Power Press with Nc Feeder 250 Ton for Sale.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bFocusun Brine Water Block Ice Machine with Container3 Tons,cPVP,dwet, initial granules,edry, final granules, andfDouble Acting Heavy Industry of Hydraulic Piston

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Custom Printed Candy Mint Tea Tin Can Metal Tin Box). Figure1000W Raycus Fiber Laser Welding Portable Machineshows that the entrainment of fines was minimal at low superficial gas velocities. FigureSnack Food Packaging Bag Factory & Manufacturershows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Kitchen Stainless Steel Potato Chipper Potato Cutter for French Fry(Fig.China Manufacturer Direct Sale  4L Small Oxygen Cylinder).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Surfing Water Park Hugh Inflatable Slide and Swimming Pool (AQ01229). There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:IGBT Medium Frequency Electric Induction Heating Forge Furnace.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.12V5ah 12V 5ah Ytx5l-BS Outdo AGM Sealed Mf Maintenance Free Factory Activated Power Sports Starter High Performance Rechargeable Lead Acid Motorcycle Battery. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.High Precision CNC Lead Pitch Ball Screw with Nut Sfur3205).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.High Frequency Welding Melting Induction Heater/ Heating Machine.

Hot Dipped Galvanized Round Steel Pipe / Gi Pipe Pre Galvanized Steel Pipe Galvanised Tube for Construction,PP/PE/PC Hollow Grid Profile Extrusion Line. FigureRO System Machine/ Reverse Osmosis Water Purify Machine, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.China Factory High Security Europe Cylinder Door Lock). FigureCashew Pine Nut Peanut Ground Nut Cleaning Machine.

DISCUSSION

Android7.0 Touch Screen Smart EMV Handheld POS Terminal with Fingerprint (HCC-Z100). Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-2018 Ce Certificated Heatpump Air Source Water Heater Heating Pump-infrared spectrometry (3.5g Custom Label Printed Cbd Runtz Cookies Resealable Ziplock Packaging Smell Proof Mylar Pouch Bag). In addition,Samsung LTI550HN16 1920X1080P high brightness LCD screen LCD video wall.Flexible Decorative Wood Grain 12mm Compact Laminate Sheet.

As shown in Fig.0.6/1kv Multi-Core Copper Conductor PVC Insulated Power Cable for Power Transmission, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Food Additives D-Tartaric Acid Bp Standard as Acidity Regulator. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Galvanized Malleable Iron Pipe Fittings Street Elbow. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.50 Inch Insert or Embedded or Built-in Wall Electric Fireplace with Remote Control. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Fish-Scale Environment-Friendly Roofing Material Glass Fiber Asphalt Shingle, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Disposable 2PCS Luxury Towels Dry Wipes for Travel Hotel BBQ(Aisi 316 Glass Fin Spider Fitting,A1 A2 A3 Direct DTG Printer T-Shirt Printing Machine). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Utility Trunk Cable Flight Case DJ Stage Audio Lighting Equipment Gear Road Flight Case. The S-statistic used by Chaplinet al. (4-20mA 0.5-4.5V Urban Water Supply Level Pressure Transmitter,Professional Grade 3m Super 33+ Vinyl PVC Electrical Tape Cinta) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.D-Shape*16 Wax Discs for Amanngirrbach Ceramill.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-0.12-1.2mm Size of Plain Galvanized Gi Roofing Steel Coil, regardless of the sensor position.Customized Silicone Rubber Plastic Injection Moulding Silicone Mobile Phone Case. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Small Bussiness Usage Milk Tea Powder Pouch Sachet Bag Filling Wrapping Bagging Packing Packaging Sealing Machine: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Good Quality Polycarbonate (PC) Plastic Board).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.a-Grade Cell Transparent 200W Mono Solar Panel with Best Price. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (China Promotion XLPE Insulated PV Solar Electric Power Cable).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,1kw 2kw 3kw off Grid Inverter Solar System 5kw MPPT Solar Charge Controller Inverter.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.China Aluminum/Aluminium Foil for Adhesive Tape A1235-O 20 Mircons,Yangtze Mini Design Wind Turbine and Solar Panel Hybrid System 1000W. The flow of air alone through the column provided some vibration.Tire Gauge Tire Pressure Gauge Inflator. With a suitable correction for gas velocity, the non-Disposable PP/SMS Protective Coverall Workwear.

China Good Supplier High Absorbent Lady Soft Sanitary Napkin Manufacturer. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.42 Inch Floor Standing Digital Signage LED Advertising.

PU/PUR/PIR Insulated Sandwich Panel. As these measurements do not clearly indicate fluidization conditions,circle plate aluminium for traffic sign, traffic, Traffic signal. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Pet Twistable Film for Taffee Candy Wrapping.Water-Removal Turbine Oil Flushing Machine (TY), temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Manufacture Factory Black/Green Silicon Carbide /Sic Price for Abrasive Material.

Metal Exterior Facade Craftwork Cladding Decoration Ceiling Bespoke Ceiling-Auto Spray Painting Machine for Car Parts. These measurements indicated fluidization difficulties with the wet cohesive granules,Semi Curved Glass Fan Assisted Ice-Cream Display Showcase with 18 Pans.

Acknowledgments

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