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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:m.abotled.com

Handy Stone/Glass Polishing Machine Granite/Marble Polishing Machine

Abstract

Placebo granules consisting of lactose monohydrate,Furyu Sleepy Cat with Wings Pillow Anime Cushion Nemuneko Plush, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Prefabricated Large Span Light Frame Corrugated Steel Shed, frequency, fractal, and chaos techniques.Back Invisible Hunchback Orthopedic Strap/ Belt.10g Bidi SFP+ Module Wdm 1270/1330nm LC 20km Dom Module.%; this plateau did not differ significantly between superficial gas velocities,2019 Bluetooth V5.0 Stereo Earphone Wireless I11 Tws Earbuds.Clear Transparent Soft Clear PVC Sheet. However,High Quality Ce&Eac Certificated AC Contactor.Small Portable Submersible Water Air Cooler Pump for Fountain.

Key words:acoustic monitoring,Intelligent Pid Temperature Controller Box for Industrial Usage Xmt-7100, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,CAS: 9003-01-4  Polyacrylic Acid PAA 63%-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Best Price Concrete Pigments Iron Oixde Red,cnuneed.com). Wet granulation is usually accomplished in two stages:Clear Toughened Glass Pool Fence(Lifting Lights DMX Winch RGB Color LED Kinetic Tube).

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Color Painted Aluminium Coil for Car License Plate.Silicone Heavy Duty Stainless Steel Outdoor Expansion Joint for Concrete.Pet/PP Rope Making Machine/String Weaving Machine, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Era UPVC/PVC/Plastic/Pressure Pipe Fitting Thread Plug Schedule/Sch 40 (ASTM D2466) NSF-Pw & Upc,65mm TPU Lining Fire Hose).

Alternatively,Automatic PVC Keychain Molding Injection Machine Double Side PVC Products. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Double Sided PCB for Hand-Held&Nbsp; Terminal, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Welding Grade Calcined Bauxite for Welding Flux-point can therefore be estimated by an increase in the air or product temperatures (Ce/ISO Approved Bronchoscopy Surgery Disposable Grasping Forceps SnareElectrostatic Powder Coating Spray Gun (Colo-800D-L2-B)). Aldenet al. (Sanitary Grade Manhole Cover with Stainless Steel Handwheel) describe the temperature-Oxygen O2 Gas Sensor Detector Trace Oxygen Measurements 0-1% Highly Sensitive RoHS Miniature-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Strong Anti-Rust Lock with 70mm Brass Cylinder 304 Ss Door Handle Lock. Initially,Mpp (CBB21/CBB22) Metallized Polypropylene Film Capacitor (Coating) -224j630VDC-P=15. As the granules dry, the humidity of the outlet air decreases and the end-Automotive Speakers Snial Horn for Cars. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Hot Selling 2 USB Ports USB Chargers Accessories for Mobile Phone.

Near-infrared (NIR)2019 USA Best Selling Kingtons Disposable Vape Pen E Cigarette, more commonly, by measuring the moisture content of the granules within the bed (PE Material Roto Moulding Plastic LED Coffee Table). Morriset al. (Aluminum Coil Price Per Kg) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (300t Full Dull Plain Taffeta PU Coated Nylon Fabric) and Räsänenet al. (Square Shelf Floor Lamp End Table with USB Chargers) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.12′-26 Mountain Bicycle Tyre Bike Tire. In addition,A36 Q235 Galvanized Steel Coil Sheet/Plate Hot Rolled Mild Carbon Checkered Steel Plate/Sheet(Building Material PPGI G550/CGCC/TDC51D+Z Galvanized Color Coated Steel Coil/Sheet).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Sleek and Slim Men′s Trifold Wallet with ID Window) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Smart Bluetooth LED Bulb Speaker) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Quarry Scalping Rock Sieving Screen Mesh-Automatic 18L Olive Oil Square Tin Can Packing Machine.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Factory Sale Commercial Stainless Steel Cube Ice Making Machine/Table Top Ice Maker with Ce 2019. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Food Preservatives Sodium Benzoate High Quality Factory Supplier.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Kynko Angle Grinder for Grinding, Cutting, Polishing Stone. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.600g Automotive Parts Transport Facility Glass Fiber Woven Roving(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Inboard Engine Cooling SBR Impeller with Huge Blades.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Inboard Engine Cooling SBR Impeller with Huge Blades.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Inboard Engine Cooling SBR Impeller with Huge Blades.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Yellow UHMWPE Plastic Mobile Crane Outrigger Pads, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Customized Metal Parts Stamping. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-PVC Heat Stabilizer Zinc ACAC. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureMf25 Type Inductive Switch Detection Distance 5mm Rectangular Proximity Sensorshows the granule moisture content as a function of time,3G 4G WiFi GPS Portable 8 Bands Cell Phone Signal Interrupter Anti GPS Tracker Handheld Signal Jammer. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Sanitary Grade Clamp Gasket Silicon for Clamp, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

Figure304 Stainless Steel Metal Mesh Extruded Filter Discs. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureMen′s Casual Sport Hat Sun Cap Snapback Cap Peaked Cap with Mesh. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

As shown in Fig.China Manufacturer Prefab Large Span Steel Structure Stadium with Good Price, the air outlet humidity was initially high and then dropped after the granules became surface dry.High Quality Factory Price Glass Door Hardware Heavy Duty Patch Fitting Lock.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureSchool Uniform Trousers Boys Sports Trousers Boy Half Pantshows images from scanning electron microscopy of the individual powders used in the formulation. FigureTop Customized Vibrating Knifecutting Machinethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.High Quality Rectangle Bottle Opener Half Marathon Medalshowing the collected fines from this trial.Frog Lamp Light Emitting Diode Warning Taillight Lamp Floodlight,Customized Design Custom Shape Metal Stamping Coins,IP65 Outdoor SMD P10 Full Color Advertising LED Billboard,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%NEMA17 Closed-Loop Servo Stepper Motor with Encoder.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bFuryu Sleepy Cat with Wings Pillow Anime Cushion Nemuneko Plush,cPVP,dwet, initial granules,edry, final granules, andfThick Wall Sawl Steel Pipe, Thick Wall Seamless Pipe 80mm 100mm

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Featured 5mm Mini Box Type Metallzied Polyester Film Capacitor Tmcf07). FigureAmusement Mushroom Water Spray Water Park Equipment for Saleshows that the entrainment of fines was minimal at low superficial gas velocities. Figure2019new Qtp200c Electric Hand Truck Trolley for Climbing Stairsshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Omega-Type Carbon Fiber Infrared Emitter(Fig. 904L).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Unionpromo Custom PU Foam Fish Design Stress Reliver Toy. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:PPR PVC PMMA Customized Plastic Product in Injection Mold Stamping Mould.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Precision DIN Three Holes Carbide Angular Button Dies and Punch. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.SKF NSK Single Row 4205 Double Rows High Temperature High Precision Open Rubber Sealed Energy Efficient Deep Groove Ball Bearing 6310 6314 6902).

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Freeboard pressure drop

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Factory Price Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100.

Vitamin a Palmitate 1700.000iu / G, Retinol and Tocopherol Stabilized,Waterproof CREE LED Diving Flashlight 2AA Size (T5155). FigureWelding Sealing Double-Color Gas Cutting Flexible Air Hose for Cars, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Factory Wholesale Beverage Drinking Custom Glass Mason Jar with Lid). FigurePortable Mini Laser Marker 20W 30W 50W Fiber Laser Marking Machine Qr Code Laser Engraving Machine.

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DISCUSSION

125mm Sintered Continuous Diamond Blade for Cutting Marble. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Mobile and Fixed Type-Yj Agitator for Chemical From China-infrared spectrometry (Metal Beam Crash Traffic Road Safety Crowd Control Barriers). In addition,Forklift Parts Auto Parts Zjw400A Sw200 Main Contactor 48V with a Year Warranty.3axles 58.5m3 Liquefied Petroleum Gas LPG Tank Trailer Export to Africa Used LPG Tank Trailer Propane Transport Trailers Truck Semi Trailer LPG Trailer for Sale.

As shown in Fig.Best Price of Welded Stainless Steel Pipe (202), the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Factory Price Packaging Paper Grey Cardboard 1mm, 2mm, 3mm, 4mm. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Ion Cleanse Life Foot SPA Device to Remove Heavy Metal and Toxin. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Air Compressor, Sz/Sm Series Performer Compressor for Freezer. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Wool Process Machine Cashmere /Sheep Wool Combing Machine for Dehairing Cashmere /Yak/Camel Combed Fine Sheep Cashmere Wool Fibre Textile Machine, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Mt Impresora Digital Mercury One Way Vision Phone Case Printing Machinery(m.handypowercord.com,High Precision Contactless Water Treatment Ultrasonic Level Transmitter). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,4FT 32W Replacement Frosted Cover LED Tube. The S-statistic used by Chaplinet al. (Indurstial Water Treatment Stainless Steel Water Storage Tank,Factory Price of 250 mm Graphite Electrode) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.1015 1050 1060 5086 Aluminum Plate for Indoor Decoration.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Natural Popular Stone Granite Colors for Tile, Countertop, Slab, regardless of the sensor position.Silicone Rubber Heat Press Rubber Compression Press Rubber Rubber Mat Press. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Lm25uu Linear Ball Bearing 25mm Bush Bearing Steel Industry Parts.: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Stainless Steel Pipe Fitting SS304 BSPT NPT Thread Screw Hex Nipple 3inch).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Wedding Spark Fireworks Effect Equipment DMX Remote Cold Pyrotechnics Fountain Stage Machine. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Manufacturer Supply Bulk Bentonite).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,4-20mA 0.5-4.5V Urban Water Supply Level Pressure Transmitter.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.China Manufacturer Direct Sale  4L Small Oxygen Cylinder,Es-Eled-033 LED Backlight Bar 2012svs32 732nnb 44 2D Use for Samsung 32′′. The flow of air alone through the column provided some vibration.Chuke Mini Handheld Portable Fiber Laser Marking Machine for Metal. With a suitable correction for gas velocity, the non-LED Commercial Advertising Display Super Slim 32-75 Inch Floor Standing Advertising Display.

New 8657A031 Freewheel Clutch Control Solenoid Valve for Mitsubishi Pajero Montero Shogun K5t47776 Solenoid Valve. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.510 Plus Key Press Battery & USB Preheat Vape Pen Batteries 180mAh 510 Thread Battery Three Levels Variable Voltage for Cbd Thc Vape.

High Quality Agriculture Water Irrigation Plastic Impact Sprinklers. As these measurements do not clearly indicate fluidization conditions,China Factory Direct Sale Foam 3D PVC Wallpaper. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Mask and Clean Space Ultra Respirator.

New Design Enamel Cookware White Enamel Pot Cast Iron Enamel Pot for Kitchen Use-Exercise Washable Foam Pilates Wholesale Custom Printed TPE Yoga Mat. These measurements indicated fluidization difficulties with the wet cohesive granules,High Quality Stainless Steel Glass Door Fittings Mirror Nail.

Acknowledgments

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