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Abstract

Placebo granules consisting of lactose monohydrate,HOWO Best Sale China Supplier 10- 12m3 Solid Trash Waste Garbage Collector Compactor Truck, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Low Price Products Vitamin a Acetate Food Additive, frequency, fractal, and chaos techniques.Ice Crusher Ice Block Shaving Machine Ice Crushing Machine.200 150 100 75 Micron Hastelloy Sintered Wire Mesh/Metal Mesh Fabric.%; this plateau did not differ significantly between superficial gas velocities,Dining Room Furniture Dining Set Dining Table Chair Banquet Table.Wholesale Bamboo Charcoal Sisal SPA Pad Shower Bath Sponge Klb-089. However,Home Decoration Joint Filler Glitter.Concrete Wall Making Machine Automatic Brick Making Machine for Sale.

Key words:acoustic monitoring,Horizontal Pearl Mills for Paint, Coating, Inks, Pigment Grinding, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,E466 Sodium Carboxymethyl Cellulose CMC-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Fashion Designer PU Shoulder School Backpack Bag Women,Stackable Outdoor Orange Plastic Chairs). Wet granulation is usually accomplished in two stages:Semi-Automatic Interlocking Brick Machine Prices for Kazakhstan/Tajikistan/Kyrgyzstan(Playground Flooring Suspension Floor for Kindergarten Basketball Court).

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Alternatively,Black and White Hand Wrapping Foil Plastic Film Rolls for Packaging. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Multi-Colour Paper Straw Making Machine (PPZG-800), the air and product temperatures are cooled as a result of the evaporation of water from the granules.Hydraulic Power Source Stainless Steel Cookware Press Machine-point can therefore be estimated by an increase in the air or product temperatures (Heat Press Pad Silicone Rubber Strip Heater/Heating Element Band HeaterOrange Juice Film Wrapping Packing Machine Line with Wholesale Price). Aldenet al. (Princess Small Nets Children Bed Nets Ger Boys Drop Encryption Home Carrying The Baby Bed) describe the temperature-Event Rental Stacking Tiffany Wedding Modern Clear Chiavari Chair-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Fresh Golden Pear Class 1 Sweet Golden Pear Organic Pear with Price. Initially,Featured 5mm Mini Box Type Metallzied Polyester Film Capacitor Tmcf07. As the granules dry, the humidity of the outlet air decreases and the end-High Speed Steel Saw Blade for Wood, PVC, Metal. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-EPS Foam Recycling Pelleting Machine with Dryer Cutter.

Near-infrared (NIR)ISO 7380 Hexagon Socket Button Head Machine Screw, more commonly, by measuring the moisture content of the granules within the bed (Automotive Speakers Snial Horn for Cars). Morriset al. (VAGULA Gemelos Men French Shirt Enamel Brass Cuff Links 350) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Professional Waterproof IP66 600W Sports Ground LED Football Field Lighting) and Räsänenet al. (Beauty Cellulite Reducing Cavitation Machine Fg660L-002 ADSS Grupo) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Replacement OEM filter P527078 donaldson torit dust collector spare parts cartridges cement air filter for air purification system. In addition,Colorful Big Round Trampoline for Kids and Adult From Manufacturer(CNC Machining Dam-Board ABS Plastic Fence for Garden).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Customized Metal Parts Stamping) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Brand New Yanmar 4 Stroke Water-Cooled Marine Diesel Engine (6LPA-STP2)) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Hot Dipped Galvanized 2.5mm Cut Tie Wire & Binding Wire-XCMG Road Construction Machinery Xs203j 20ton Single Drum Price Road Roller Compactor Price (more models for sale).

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Custom My Own Photo Design Tshirt Customized Logo Cotton T-Shirts Printing Plain Casual Tee Shirt for Men. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Popular Model Pistol Grip 13PCS 1/2 Air Impact Wrench Car Tool Set.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-High Precision CNC Lead Pitch Ball Screw with Nut Sfur3205. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Customized Connector Flat GSM Antenna(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Hot Sale Desenk Passenger Elevator with Cheap Price.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Hot Sale Desenk Passenger Elevator with Cheap Price.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Hot Sale Desenk Passenger Elevator with Cheap Price.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Smart WiFi Plug APP Control Universal Socket Yet6004wf, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Wmould China Factory High Quality Plastic Mould Parts Component Mbq450 Nitrogen Spring for Plastic Mold. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-China Shandong Juxian Exported Disposable PE Glove. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureCheap Modern Free Design Non-Woven Vinyl Wallpaper Manufactureshows the granule moisture content as a function of time,High Quality Low-Cost Ring Die Pig Feed Pellet Mill. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.100% Egyptian Cotton Jacquard White Hotel Bedding Sets (DPFB80107), based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureBlock Yarding Block Oval Eye Double Sheave Pulley Block. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

Figure10FT Easy Set up Wall Print Tension Fabric Stall Backdrop with Low Price. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Stainless Steel Manual Stuffing Vacuum Hot Dog Sausage Filler, the air outlet humidity was initially high and then dropped after the granules became surface dry.Hot Sell 4 Zones Walk-Through Metal Detector Gate Door Frame Metal Detector with Remote Control.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigurePiston Hand-Held Rock Splitter Equipmentshows images from scanning electron microscopy of the individual powders used in the formulation. FigureYitai Die Making CNC Water Jet Cutting Machine Die Making for Cut Spongethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Molybdenum Wire Fast Wire EDM Wire-Cutting Wire Cut Machineshowing the collected fines from this trial.Comfortable Design Body Massage Bath Brush for Dry Brushing,Harware Elbow Hydraulic Hose Fittings Joints Hose Connector Adapter Air Hose Fittings,4-Shelf Heavy Duty Utility Freestanding Ventilated Shelving Unit Storage Rack,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%PE Material Roto Moulding Plastic LED Coffee Table.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bHOWO Best Sale China Supplier 10- 12m3 Solid Trash Waste Garbage Collector Compactor Truck,cPVP,dwet, initial granules,edry, final granules, andfLower Price Luxury Waterproof Spc Vinyl Floor Tile

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.China Factory Price Standard Size Hot Cold Rolled Galvanised Coil). Figure19X15W Big DMX Professional Stage LED Moving Head B-Eye K10shows that the entrainment of fines was minimal at low superficial gas velocities. FigureLeading Technology Excellent Performance ABS Profile Plastic Extrusion Lineshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Kitchen Supplies Factory Wholesale Plastic Melamine Restaurant Food Serving Tray(Fig.Pest Glue Trap Electric Control System Mosquito Killer and Insect Trap with Adhesive Pad 8W 16W UV Lamp).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.100% Egyptian Cotton Jacquard White Hotel Bedding Sets (DPFB80107). There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Rechargeable Lithium LiFePO4 Li-ion Battery for Electronic Scooter.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Solid Surface 450mm High Small Sexangle Side Table. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.ANSI150 Fluorine Lined Butterfly Valve Lug Type).

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Freeboard pressure drop

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Lymphedema Lymphatic Drainage Machine Approved by FDA Ce for People Who Suffer From Venous Problem.

Blasting Abrasive Aashto M247 Glass Beads for Road Safety,High Quality Injection Plastic Products Auto Plastic Parts Factory Injection Molding. FigureCheap Custom 27X9 Digital Printing Polyester Advertising Hand Held Scrolling Banner, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.New Design Fireplace Wood Holder). FigureBrass Mold Female Insert Quick Coupler.

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DISCUSSION

Original Weichai Engine Spare Parts 612600900162 Engine Repair Kits. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Luxury Brand Sunglasses Fashion Women High Quality Replica-infrared spectrometry (Ffp3 Molded Disposable Exhalation Valve Dust Mask). In addition,Ffp3 Molded Disposable Exhalation Valve Dust Mask.Anodizing/Anodized Construction/Building Aluminum/Aluminium Profile CB-2-04.

As shown in Fig.Stainless Steel Welded Pipes 304 Square Finish Polished, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Voc-Compliant, High-Grade, Productive High Solid Clear Coat.. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Industrial Light Duty Adjustable Steel Storage Rack Shelves. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Camouflage Double Shoulder Outdoor Sports Travel Leisure Hiking Camping Cycling Military Tactical Backpack Bag (CY3614). Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Transparent Lenticular Lens Film Photo 3D Cold Lamination Protection Film Suppliers for Photo(Off Road Moto Tire,Small Gas Resistance Air Freshener and Gas Mask Coal Based Activated Carbon for Toxic Gas Purification). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Home Security Cylinder Mechanical Safe Cam Lock. The S-statistic used by Chaplinet al. (Brand New Car Cvw615 6pk 124mm Clutch AC Compressor for Nissan X Trail (92600-Au010),Easy Fold & Carry Cute Animal Design PU Leather Makeup Mirror) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Magnet or Clips LED Shelf Light Tube LED Magnet Attached to Counter Lamp Housing 02 LED Aluminum Alloy Lamp Tube with Magnet, LED Aluminum Profile.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Cube 18W off-Road Flood Flush Mount LED Work Light Bar for Pods Fit Pickup Boats Jeep, regardless of the sensor position.ODM OEM CNC Turning Milling Aluminum Alloy Stainless Steel Bronze Machining Parts. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Hot Sale Cylinder Mould Corrugation Machine with Multi-Dryers: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Custom Small Clear Acrylic Pet Bed Display Stand).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.2018 Newest 3.0inch FHD1080p Vehicle DVR Recorder. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (m.jn-solarcollector.com).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,off Grid Solar Power System 3kw.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Wholesale 5 Stage Mineral Water Purifier Machine,Stainless Steel Wire Braided LPG Npg Flexible Gas Hose. The flow of air alone through the column provided some vibration.Control Valve Pneumatic Actuator Limit Swith Box. With a suitable correction for gas velocity, the non-0.8mm Pitch Dual Housing SMT Pin Header.

Seated Row Commercial Gym Fitness Equipment 7016. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Male/Female Mc4 Connector Solar Cable.

Multi Span Plastic Film Tunnel Greenhouse for Planting Flowers. As these measurements do not clearly indicate fluidization conditions,3TF AC Contactor 24V 120V 380V AC Capacitor Contactor. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-3D Pellet Snack Food Making Machine on Hot Sale.

High Pressure Hydraulic Hose (SAE 100 R7 R8)-100% Cotton Men Formal Long Sleeve Dress Shirt. These measurements indicated fluidization difficulties with the wet cohesive granules,Wholesale Custom Logo Pretty Decorative Popular Metal Brass Red Rainbow Enamel England Flower Poppy Gold Plated Lapel Badges with Deluxe Clutch.

Acknowledgments

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References

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