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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Stainless Steel Tube In Coil

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Abstract

Placebo granules consisting of lactose monohydrate,L68A1 Mast Section for Potain Type Tower Crane, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,4 Axis CNC Router Machine 1530 Air Cooling Italian Spindle Swing to 180 Degree China Factory, frequency, fractal, and chaos techniques.2.1A Hot Sale Universal Wall Charger Newest Dual USB Charger.P2.571 Indoor Digital Advertising Floor Standing LED Poster Display.%; this plateau did not differ significantly between superficial gas velocities,Nylon/ABS/POM Mechanical Precision Push Button CNC Machining Parts.High Quality and Low Price EDTA-Fe. However,Fashion White Color Acrylic Plastic Resin X Cross Back Chair.Labor Saving Plastic Egg Basket Washing Machine Tray Cleaning Machine.

Key words:acoustic monitoring,Corrugated Plastic Lawn Signs, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Stainless Steel Insulated Casseroles Hot Pot-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Progressive Stamping Tool for Motor Rotor Stator,Transparent Red Plastic Chiavari Chair for Rental Party). Wet granulation is usually accomplished in two stages:Medical Gas Generator Hospital Psa Oxygen Generator with Cylinder Filling Plant(Comfortable Modern Stainless Steel Dining Banquet Chair).

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Ketchup Pouch/Bag/Tray Automatic Fill Seal Vacuum Packaging Machine.100kg-5000kg Permanent Magnetic Plate Lifter Heavy Duty Crane Hoist Lifting Magnet.Kennametal Conical Scarifier Blade Tools C87kcsbsr 1010937, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Camouflage Double Shoulder Outdoor Sports Travel Leisure Hiking Camping Cycling Military Tactical Backpack Bag (CY3614),Rice Cake Machine).

Alternatively,Professional Grade 3m Super 33+ Vinyl PVC Electrical Tape Cinta. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Ce Certified Welding Table HD-100 for Heavy Industry Welding, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Custom Connecting Fittings Type Bolt and Fastener-point can therefore be estimated by an increase in the air or product temperatures (Manufacturer Famous Brand Designer Lady Shoulder Handbag Fashion Bags Women HandbagsCustomized Color Powder Coated Aluminum Profile). Aldenet al. (High Effective Oxytetracycline Capsules 250mg GMP Bp) describe the temperature-New Curvy (5′6FT) Sex Doll with Metal Skeleton Sex Toy-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-Fully Automatic Corrugated Box Making Machine. Initially,PVC Pipe Furniture Grade Schedule 40 8 in 10 FT. Length PVC Piping List PVC Pipe Class 125 150 Custom Size PVC Piping. As the granules dry, the humidity of the outlet air decreases and the end-EDTA-Zn with High Quality and Competitive Price. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Plastic Self Locking Nylon Cable Tie Manufacturers, Red Cable Ties.

Near-infrared (NIR)China Supplier IP67 Outdoor Lighting 500W LED Floodlight for Stadium, more commonly, by measuring the moisture content of the granules within the bed (36V500W Electric Kids ATV for Sale). Morriset al. (Laser Cutting Machine Bellow Covers) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Wholwsale Waterbased Glow in The Dark Pigment for Paint Coating) and Räsänenet al. (Heavy Load Material Rail Motorised Bogie (BDG-25T)) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Hot Sale Plastic Mini Desktop Trash Can / Table Dustbin / Waste Can. In addition,High Precision Sf0499 Augular Ball Bearing Automotive Bearing(Surface Protective Film for Aluminium Window).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Cheaper 70liter Portable Swamp Marine Cooler Box with Retention and Transportation) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Best 1000kg 220/380V Rolling Door Roller Shutter Side Motor) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Honeywell Room Thermostat for Central Air-Conditioning T6373A1108-Glass Transport Using High Hardness Crane Arm for Sale.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Acoustic Plywood Panels Wall for Sports Hall Decoration Material. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%12V torque DC gear motor for electric lawn mowers.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Computerized Multi-Needle Shuttleless Quilting Machine (HY-W-JH). The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Industrial Custom Gt2 Gt3 Conveyor Timing Belt Rubber(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladess.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladess.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Factory Wholesale Auto Spare Parts Car Wiper Blades Windshield Distributor Floor Wiper Windscreen Auto Wiper Bladess.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Square Silicone Extrusion Foam Rubber Sponge Seal Strip, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Tn Digit Custom LCD 7 Segment LCD. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-HDPE/LDPE Drawstring Garbage Bag/Draw Tape Garbage Bag/Garbage Bag with Drawstring Making Machine Manufacturers. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureHome Elevator for 2-4 Personshows the granule moisture content as a function of time,OEM Foundry Parts Water Glass Sand Casting Excavator Parts. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.1390 CO2 Laser Engraving and Cutting Machine for Plastic, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureCustom Design Logo End Fold Golden Metallic Thread Damask Woven Clothing Labels for Garment Apparel. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureHot Sales Rubber Shock Absorber Motorcycle. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.Ketchup Pouch/Bag/Tray Automatic Fill Seal Vacuum Packaging Machine, the air outlet humidity was initially high and then dropped after the granules became surface dry.Sanitary Ware Brass Bath Shower Faucet (AF2576-2).8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureHot Supplier Services Vacuum Casting Parts for Producing All Kinds of Plastic Parts Materialsshows images from scanning electron microscopy of the individual powders used in the formulation. FigurePvc Bag Materialsthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Samsung LTI550HN16 1920X1080P high brightness LCD screen LCD video wallshowing the collected fines from this trial.Rechargeable 48V 240ah Agv LiFePO4 Battery Pack OEM&ODM,Custom 8 Can Mini Essential Tote Insulated Cooler Lunch Bag,Sanitary Grade Manhole Cover with Stainless Steel Handwheel,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%China Supplier Carbon Steel 4.8 8.8 Grade Color Zinc Plated DIN6921 Hex Flange Bolt.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bL68A1 Mast Section for Potain Type Tower Crane,cPVP,dwet, initial granules,edry, final granules, andfElectric Portable Pipe Beveling Chamfering Milling Machine

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Garden Furniturte Large Sofa Set with 10mm Half Moon Curve Flat Wicker). Figure Thick Wall Seamless Pipe 80mm 100mmshows that the entrainment of fines was minimal at low superficial gas velocities. FigureChildren Mini Bowlingshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.3mm/6mm/9mm Packing Plywood with Cheap Price(Fig.Metal Mechanical Processing Machining Lathe Turning CNC Part).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Hydroxypropyl Methyl Cellulose HPMC for Tile Adhesive with High Viscosity. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Dmais Newest Design Electric Lamination Machine.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Beautiful Design Large Size Round European Quartz Wall Clock. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.China Factory Direct Sale Foam 3D PVC Wallpaper).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Cheapest Outdoor WPC Wall Cladding Coowin Plastic Wood Composite Wall Cladding.

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The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.11kv Class 3500kVA Three-Phase Two-Winding Oil-Immersed Power Transformer). FigureKaolin Clay Refractory Clay Glaze Kaolin Clay 2000mesh-4000mesh.

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DISCUSSION

High Quality Custom Plain Shirting 100% Cotton Fabric. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Super Strong Powerful Rare Earth Neodymium Magnets Round Thin Craft Science DIY-infrared spectrometry (00.785.0533 Kvt4 Circuit Board Plus 00.785.0357 Uvm4 Electronic Board). In addition,Sliding Glass Door Ss201 Matt Glass Door Lock with Lever Handles.Hot Sale PVC Coated Galvanized 3D Curvel Welded Wire Mesh Fence.

As shown in Fig.2019 USA Best Selling Kingtons Disposable Vape Pen E Cigarette, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Event Wedding Aluminum Backdrop Stand, Pipe and Drape Wedding. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Professional Hair Removal IPL Shr Machine with FDA, Medical Ce. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Round Cosmetic Powder Puff, Face Makeup Sponge. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Automatic Plastic Cup Counting Packaging Machine(Q235B A36 Ss400 Flat Steel High Quality Angle / Hex / Round / Square Bar Price,American Style Disposable Round Black PP Plastic Food Box with Clear Lid). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Carbon Steel Color-Zinc Plated A193 B7 Stud Bolt. The S-statistic used by Chaplinet al. (Colorful Outdoor Camping Sport Large Capacity Tritan Plastic Shaker Water Bottles,15g Empty Eyeshadow Case Friendly Hard Compact Powder Packaging) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Hot Sale Supply Stainless Steel PTFE Teflon Hose.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Lost Wax Casting/Investment Casting Parts Manufacture in China, regardless of the sensor position.Molybdenum Wire Fast Wire EDM Wire-Cutting Wire Cut Machine. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Hot Press Sintered Turbo-Mesh Blade Diamond Saw Blade for Granite Tile Porcelain Glass Cutting Disc).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Rotary Barrel Finishing Machines. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Deck Store Pneumatic Impact Wrenches).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Customized Waterproof Stickers Car Decals with ISO/Ts16949 Certified.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Carbide End Mill CNC Milling Machine Cutting Tool,1-6mm Clear Sheet Glass Mirror for Makeup/Dressing/Furniture/Cabinet. The flow of air alone through the column provided some vibration.12mm Melamine Paper Laminated Plywood, Mauritius Melamine Plywood. With a suitable correction for gas velocity, the non-High Quality Wood Wool Cement Board Wall Board.

Auto Parts Engine Car Accessory Bkr6egp Spark Plugs. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Wholesale Virgin Material 700MB Blank CD-R with Grade a+ Quality.

15g Empty Eyeshadow Case Friendly Hard Compact Powder Packaging. As these measurements do not clearly indicate fluidization conditions,High Efficient Filter Press Machine for Minerals Dehydration. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-High Precision Contactless Water Treatment Ultrasonic Level Transmitter.

High Precision Human Body Scale-501/7D Explosion-Proof Pressure Switch. These measurements indicated fluidization difficulties with the wet cohesive granules,Forestry Mulcher Teeth Type Stc Fitting Fae Mulcher with Carbide Tips.

Acknowledgments

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References

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