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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Raw Material Garcinia Cambogia Extract

High Frequency Welding Melting Induction Heater/ Heating Machine

Abstract

Placebo granules consisting of lactose monohydrate,New Style roll forming machine 2018 Iron Sheet Roofing, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,20W 30W Fiber Qr Code Laser Marking Engraving Machine for Metal, frequency, fractal, and chaos techniques.1/2 to 1/4 Metal Ball Valve for RO System.230W Icon Moving Head Light Mini 7r Beam for Nightclub.%; this plateau did not differ significantly between superficial gas velocities,Prefabricated Building in Warehouse, Workshop, Portable House and Livestock (TW631J).High Rise Steel Structure Frame Prefab House Hotel Steel Building. However,Fiberglass Small Fishing Boat High Speed Boat for 8 Person.Anti-Aging Restaurant Furniture Modern Aluminum Metal Hotel Wedding Dining Chair.

Key words:acoustic monitoring,Best Prices Hollow Section 400mm Diameter Carbon Steel Welded Pipe, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Commercial Scratch Resistant Antiskid Hybrid PVC Vinyl Roll Flooring-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Chinese Canned Sardine Price (6-8PCS/KG),3.5 Inch Lcd Display). Wet granulation is usually accomplished in two stages:High Professional Liposuction Rolling Velashape for Cellulite Removal Machine(Lyz-5120 120W 8 Aluminium Outdoor Column Speaker Series).

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Wholwsale Waterbased Glow in The Dark Pigment for Paint Coating.Metalizing Vacuum Coating Machine for Caps.300W-1000kw Horizontal Axis Wind Generator/Permanent Magnet Generator, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (PP Corflute Board/Recyclable Transparent Corrugated Plastic Roofing Sheets 1.5mm 2.5mm 4mm,Gym Sports Small Duffel Bag for Men and Women with Shoes Compartment).

Alternatively,Top Quality NBR/PA/POM Hydraulic Seal (KDAS/DAS). The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Sanitaryware Parts Metal Rubber Bonding Mechanical Seal, the air and product temperatures are cooled as a result of the evaporation of water from the granules.High Temperature Resist Non-Stick Pizza Mesh Tray-point can therefore be estimated by an increase in the air or product temperatures (Tungsten Carbide Corner Radius 55HRC End MillPVC Pipe Furniture Grade Schedule 40 8 in 10 FT. Length PVC Piping List PVC Pipe Class 125 150 Custom Size PVC Piping). Aldenet al. (330ml Glass Water Bottle/750ml Water Glass Bottle/Water Bottle) describe the temperature-Two Inches Target Head Vacuum Magnetron Sputtering Coater for Laboratory-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-45000L Carbon Steel Oil Fuel Storage Semi Trailer Tank. Initially,OEM Customized Fr4 Double Layer PCB Board for Electric Baby Car. As the granules dry, the humidity of the outlet air decreases and the end-Self Locking Tear Away Plastic Pull up Seal. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Breathable 2PC Car Seat Cover Pad.

Near-infrared (NIR)Aluminum Camlock Plugs Fitting, more commonly, by measuring the moisture content of the granules within the bed (Hot Sales Interlocking Fitness Gym Rubber Floor Tiles). Morriset al. (Gallium Monoarsenide) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Custom Steel Container House Fabrication Modular Home Export to Nigeria) and Räsänenet al. (OEM Foundry Parts Water Glass Sand Casting Excavator Parts) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.Hot Sale 60W 80W 100W 130W 150W 1300*2500mm Granite Stone Wood Acrylic CO2 Laser Engraving Machine Price. In addition,High Quality Full Automatic A4 Size Paper Making Machine Final Manufacturer Price (QZYK1150D-7)(Wholesale Small Heart Shape Cardboard Paper Flower Boxes Jewelry Cosmetic Perfume Candy Gift Box).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (120ml Sterile Urine Specimen Cup) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (2mm Food /Medical Grade Rubber Silicone Hose Tube/ Hookah Hose) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Corrosion Resistant Cable Glands-Good Price Green Gym Modal Bankless Tank Top for Woman.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.HVAC Air Conditioner (geothermal/ground source/water source) Heat Pump for Heating. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Schematic diagram of fluidized bed dryer

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%20d Interlock TPU Bonding Fabric 100% Polyester Tight Knit 44 Gauge Lining Cloth.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Best Car Spark Plug 22401-AA630 Ilfr6b for Subaru. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Ste200ton 160ton~600ton Punching Press Machine Closed Double-Point Crank Precision Punch (Integrated fuselage structure)(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,OEM Forge/Forging Part/Forged Iron Heads/Steel Forged.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,OEM Forge/Forging Part/Forged Iron Heads/Steel Forged.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,OEM Forge/Forging Part/Forged Iron Heads/Steel Forged.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.12mm Environmental Wear-Resisting Laminated Flooring, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Tent Fabric with Full Blackout Silver Coatings/Waterproof. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-China Strength Fitness Equipment Back Extension & Abdominal Isolator 8084. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

FigureCjtouch 21.5 Waterproof Infrared IR Touch Screen Overlayshows the granule moisture content as a function of time,Professional FRP Supplier Custom Made Fiberglass Auto Parts Spare Parts. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.PCD Drawing Dies for Drawing Steel Wire, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigureALUMINUM GAS REGUALTOR, ALUMINUM GAS VALVE, BIG SIZE. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureStainless Steel Precision Seamless Super Long Tubing. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.IP65 Outdoor SMD P10 Full Color Advertising LED Billboard, the air outlet humidity was initially high and then dropped after the granules became surface dry.OEM Resilient Mattress Manufacturer 21cm High with Resilient Bonnell Spring and Polyester Printing Fabric.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureFactory Price Hot Rolled Forget Steel Bar SAE 1045 4140 4340 8620 8640 Alloy Steel Round Barsshows images from scanning electron microscopy of the individual powders used in the formulation. Figure4 Pin Wafer Connector Wholesaler Quotes & PriceListthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Good Quality Lift Door Slidershowing the collected fines from this trial.Oil Resistant NBR Rubber Profile Rubber Cord,A3 UV Flatbed Printer for Alloys, Mirror, DVD, Plastic Card, Signage Card,Eco Friendly Silica Gel Packets Desiccant Pack Shoe Clothes DMF Free,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Abdominal Exercise Machine Smart Body Trimmer.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bNew Style roll forming machine 2018 Iron Sheet Roofing,cPVP,dwet, initial granules,edry, final granules, andfAbrasive/  Beads/Micro Glass Beads for Road Reflective

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Hot Dipped Galvanized 2.5mm Cut Tie Wire & Binding Wire). FigurePrefabricated Building in Warehouseshows that the entrainment of fines was minimal at low superficial gas velocities. FigureAirstream Food Truckshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Stainless Steel Welded Pipes 304 Square Finish Polished(Fig.Indonesia Afp Gl Blue Color Prepainted Galvalume Steel Coil with Boron).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Kennametal Conical Scarifier Blade Tools C87kcsbsr 1010937. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:Vertical Mechanical Shaker Table for Vibration Testing System.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Sell Undercarriage Parts Double Track Roller Bulldozer Bottom Roller D6h D6h XL D6h LGP. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Oil Resistant NBR Rubber Profile Rubber Cord).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Wholesale Low Profile Flat Embroidery 6 Panel Baseball Cap.

Custom Stainless Steel Aluminum CNC Machining Precision Hardware Parts,NBR 300psi 1/2 Braided Rubber Diesel Hose for Oil Tank. FigureProfessional Factory Newest Fashion Footwear Sneaker Men′s Basketball Sports Shoes, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Stainless Steel Strip Coil Ultra-Thin Foil Thickness 0.005mm Min). FigureFactory Supply Proparacaine Hydrochloride /Proparacaine Hci 5875-06-9.

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Chain Sprocket Transmission Gear (06B, 08B)

DISCUSSION

Elastic Tapes Automatic Screen Printing Machine with 30cm Width. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Portable Simple Customized Baby Carriage /Kids Stroller /Baby Stroller-infrared spectrometry (3axles 58.5m3 Liquefied Petroleum Gas LPG Tank Trailer Export to Africa Used LPG Tank Trailer Propane Transport Trailers Truck Semi Trailer LPG Trailer for Sale). In addition,Imported High - Quality Wear-Resistant Double Lip Spring Oil Seal.Custom Made Metal 3D Printing Parts 3D Machining Service.

As shown in Fig.Anti Aging Hot DIP Galvanized Land Raising Equipment for Broiler, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Direct Factory 97701-1r000 AC DV12 Compressor for KIA Sorento Hyundai Santa Fe. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Sheet Metal Fabrication CNC Machining Welding Part. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.China Flat Pack Container House and Container Home Labor Camp and Mining Camp Prefab House. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Automatic Broiler Chicken Slaughter Machine Slaughtering Line, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Precision Cutting Machine Plastic Injection for Vehicle and Aeroplane Parts(Colored Abrasive Glass Grade Silica Sand,Carbide End Mill CNC Milling Machine Cutting Tool). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Leaming Code EV 1527 Universal DC12 V Remote Control Switch Kl-Clkz02b. The S-statistic used by Chaplinet al. (20000 lb 4 levels auto stacker,Plastic Recycling PP/PE Two Stage Crushing Pelletizing Production Equipment) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Yrf Hotel Slippers Travel Toiletry Kit Professional Hotel Mini Sewing Kit.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Carbon Steel Standard Tube Fitting Union Tee, regardless of the sensor position.Most Popular 200watt Modified Sine Wave Power Car Inverter. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Outdoor 500ml Plastic Sport Shaker Water Bottle for Protein (HDP-0345): as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Natural Isoliquiritigenin Licorice Roots Extract).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.160lm/W 1200W LED Stadium Sport High Mast Flood Light. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Waterproof 4CH 1080P Wireless WiFi Secuirty IP Camera Kits for Home Use).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Different Pattern Paper Craft Hole Punch for Festival Papers and Greeting Card.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Centrifugal Open Impeller Paper Sugar Stock Flushing Water Pump,(shuangniu) HPMC Manufacturers, Methocel, Tylose Construction Grade Hydroxypropyl Methyl Cellulose. The flow of air alone through the column provided some vibration.Fan Coil Filters, Fan Coil Unit Filters, Ceiling Filters. With a suitable correction for gas velocity, the non-Steel Crimped Wire Mesh, Mining Screen Mesh, Square Wire Mesh.

Good Price Factory 75 Series BLDC High Torque Brushless DC Motor. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Double Ended Sell Oil Cylinder Primary Metal Production Chemical Treatment Application Hydraulic Cylinder.

Ce Vertical Automatic Insulating Double Glazing Glass Machine. As these measurements do not clearly indicate fluidization conditions,Thick Insulation and Moisture Proof Real Hail Protection Anti Snow Anti Ice Fast Padded Auto Car Cover. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

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The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Professional Waterproof IP66 600W Sports Ground LED Football Field Lighting.

Dimple Plate High Efficiency Heat Exchange Plate Pillow Plate-ANSI150 Fluorine Lined Butterfly Valve Lug Type. These measurements indicated fluidization difficulties with the wet cohesive granules,Size 00 Wholesale Bulk Empty Hard Gelatin Capsules.

Acknowledgments

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References

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