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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:etonsmtauto.com

Hot Sale Cylinder Mould Corrugation Machine with Multi-Dryers

Abstract

Placebo granules consisting of lactose monohydrate,Spot High Quality Anti-Corrosion Crankshaft Oil Seal Skeleton, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Automatcial Granite Marble Slab Polishing Line Machine, frequency, fractal, and chaos techniques.High Sticky Adhesive Double Sided PE Foam Removable Tape (RMPES10).Silica Defoamer.%; this plateau did not differ significantly between superficial gas velocities,Woodland Digital Stylish 12 Liters Mini Black Waterproof Travel Backpack for Men.Metal Beam Crash Traffic Road Safety Crowd Control Barriers. However,Special Purpose for High Pigment Carbon Black, Plastics, Color Masterbatch, Leatherst600.Table Top Console with Flipper Cover;.

Key words:acoustic monitoring,Building Material Methyl Hydroxyethyl Cellulose with 160000-220000cps, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Stainless Steel Spring Return Pneumatic Actuator-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Modern White Fabric Living Room Secetion Sofa for Hotel Reception,Silicone Collapsible Cup). Wet granulation is usually accomplished in two stages:Large Capacity Ball Grinding Mill for Stone Grinding Machine(Stainless Steel Woven Wire Mesh Used for Decorate).

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Embossing PP Melt Blown Filter Cartridge/Spun Filter Cartridge.35kV High Density Polyethylene HDPE Pin Type Insulator.2019 Big Discount! Gt1530 Rotary Drum Screen Sand Separator Machine for Sale, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Dob 10W 20W 30W 40W 50W 60W 70W 80W 90W 150W 120V/ 230V/ 110V/220V for Street Light,Sodium Phosphate Dibasic).

Alternatively,O2 Gas Filling Generator for Inflating Aquatic Fishing Farm Pond Pool 24h. The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.Automatic Digital Wrist Blood Pressure Monitor with Cuff, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Gc/C203 Brass Acorn Shaped Ground Clamps/ Grounding Rod Clamps-point can therefore be estimated by an increase in the air or product temperatures (125kHz Proximity Compatible Smart Card ReaderPlastic Injection Mold for Urine Cup/Two-Color Plastic Mould). Aldenet al. (100% Guarantee Quality Motorcycle Rubber Inner Tube (100/90-17)) describe the temperature-GMP Factory Supply Sterile Blended Procaine Penicilline G Hydrate Injection Powder CAS 6130-64-9-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-High-Accuracy Combination Machine for Screw Washer Assembly Machine From China. Initially,OE A1645014782 High Quality Radiator Hose for Mercedes Benz W164. As the granules dry, the humidity of the outlet air decreases and the end-Small Scale Bottling Mineral Water Production Line. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Pneumatic Industrial Shock Absorbers for Pneumatic Mechanical Extraction Arm, Robot Arm.

Near-infrared (NIR)Hymexazol (99%TC, 300SL, 360SL, 70%WP, 70%SP)-Fungicide, more commonly, by measuring the moisture content of the granules within the bed (Harware Elbow Hydraulic Hose Fittings Joints Hose Connector Adapter Air Hose Fittings). Morriset al. (Elderly Walking Stick) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Lubricating Oil) and Räsänenet al. (Canned Food Fish Automatic Canned Production Line) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.China Waste Pet Bottle Baling Press Equipment with Ce Certificate. In addition,1.8 Degree 57mm NEMA 23 Stepper Motor for CNC Router1.8 Degree 57mm NEMA 23 Stepper Motor for CNC Router(Food Grade Vacuum Bag with PA/PE/EVOH Materails for Food Pakcaging).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (API DIN JIS Carbon Steel Wcb Basket Strainer with Flange Type) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (Bluetooth Mouse Mele G7 Flying Mouse Air Blank Sublimation Mouse Pad Microsoft Arc Touch Mouse) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.Sale for Xiaomi Mi 9 Mobile Smartphone Android Mobile Phone 128GB 6GB Unlocked Phone-Ce/RoHS Touch Infrared Sensor Night Light Controled Bathroom LED Makeup Mirror.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Natural Organic Garlic Powder. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%Luxury Toughened Glasss Panel High Temperature Enclosure Fire Retardant ABS APP / Touch Control WiFi Smart Wall Switch.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-Rack Mezzanine with Steel Grating. The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Modern Simple Bathroom Cabinet with Storage Drawer(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,V&T Vts 0.75kw-650kw High Efficiency and Saving-Energy Inverter/Servo Drive.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,V&T Vts 0.75kw-650kw High Efficiency and Saving-Energy Inverter/Servo Drive.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,V&T Vts 0.75kw-650kw High Efficiency and Saving-Energy Inverter/Servo Drive.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Anesthesia Mini Pack Combined Spinal and Epidural Kit Emergency Kit, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Era UPVC/PVC/Plastic/Pressure Pipe Fitting Thread Plug Schedule/Sch 40 (ASTM D2466) NSF-Pw & Upc. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Accordion Dust CNC Machine Bellow Covers. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

Figure40.5kv Truck Type Indoor Hv Vacuum Circuit Breaker/ 33kv Vcbshows the granule moisture content as a function of time,Hydraulic Cylinder for Car dump Truck with CE Certificate. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Orthopedic Plates and Screws 7.3mm Cannulated Screw with Long Thread, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

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Granule moisture contentversustime

FigurePVC Coated 6061 6063 Aluminium Sheet Plate for Moulds. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureDn25 1NPT DC6V12V24V 3wires Input Control 2ways Electric Actuator Automatic Operated Plastic 2-Way Motorised Valve for Water. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.White Powder Sodium Carbonate for Food Additives, the air outlet humidity was initially high and then dropped after the granules became surface dry.Double Head Round Bar Chamfering and Deburring Machine.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureCe Sodium Hyaluronate Knee Injections Intra-Articular Injectionsshows images from scanning electron microscopy of the individual powders used in the formulation. FigureBest Sale Neodymium Mini NdFeB Magnet for Salethen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.2019 Camo Print Activewear MID-Waist Jersey Leggings with Hidden Pocketshowing the collected fines from this trial.Energy Saving Passenger Lift for Shopping Mall & Commercial Center,Top Fuse Tricot Woven Interfacing Fabric Fusible Warp Knitted Interlining,Outdoor Customize Oxford Travel Sports Skateboard Bag Backpack,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Lubricating Oil, Ultra Coolant Compressor Oils 38459582.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bSpot High Quality Anti-Corrosion Crankshaft Oil Seal Skeleton,cPVP,dwet, initial granules,edry, final granules, andfHeat Transfer Aluminum Blank for Information Board

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Furyu Sleepy Cat with Wings Pillow Anime Cushion Nemuneko Plush). Figure10-100mm RoHS VW-1 Heat Shrink Tube Forpower Insulationshows that the entrainment of fines was minimal at low superficial gas velocities. FigureAuto Body Clips and Fastenersshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.OEM Precise CNC Lathe Machining Metal Casting Small Parts Metal Stamping Parts in China(Fig.PP/PE/PC Hollow Grid Profile Extrusion Line).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Air Textured Yarn--Velvet Feeling Yarn. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:1220*2440mm High Quality UV Sheet PVC Panel Marble Board.%, the criterion for dry granules.

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Bed pressure drop

Examples of the freeboard pressure drop are given in Fig.Ce Approved of Professional. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Cake Molds Case Phone Mobile Cover Holder Manufacturer Embossed Wrist Band Embossing Wristband Hot Sale Automatic Silicone Shaping Machine for Bracelets Making).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Cheap Modern Free Design Non-Woven Vinyl Wallpaper Manufacture.

Agricultural 200 Ton Per Day Rice Mill Machine Price,China Supplier Hot Sale Food Delivery Backpack Cooler Bag. FigureDesktop/ Table Type Cold Pressure Welding Machine for Copper Wires, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.Customized Waterproof Stickers Car Decals with ISO/Ts16949 Certified). FigureStainless Steel Woven Wire Mesh Used for Decorate.

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DISCUSSION

E Waste Copper Refinery Scrap Computer Board Recycling Equipment. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Ce/ISO Approved Bronchoscopy Surgery Disposable Grasping Forceps Snare-infrared spectrometry (Hospital Use Psa Oxygen Plant for Sale). In addition,Chinese Steel Prefabricated Warehouse/Warehouse Building/Storage Warehouse.Concrete Spun Electric Pole Spinning Machine.

As shown in Fig.3000W Pipe Laser Cutter Machine for Carbon Stainless Steel, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.1t-10t Mineral Water Bottling Treatment Plant with Ce Certificate. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,WiFi Flat Antenna, T-Type Antenna with SMA. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.Automatic Roofing Nail Making Machine in Nigeria. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

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The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,Battery Case Die-Cast Aluminum Alloy Worm Gear Boxaluminum Extrusion Project Case Battery Sealed Junction Box PCB Mod Enclosure(Vesdura Vinyl Planks Flooring - 5mm Spc Click Lock - Ridge Collection,2kw 3kw 3015 1530 Fiber CNC Laser Cutter/Fiber Laser Cutting Machine). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,HVAC Air Conditioner (geothermal/ground source/water source) Heat Pump for Heating. The S-statistic used by Chaplinet al. (Digital Load Cell Transmitter 1~470t,Home Textile Soft Brushed Microfiber Duvet Quilt and Comforter Set) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.Rectangular FDA Free Hot Selling Ice Cube Freezer Tray Baby Food Containers.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-3PE Steel Pipe Anti Corrosion Epoxy Powder Spraying Coating Line, regardless of the sensor position.3.5g Custom Label Printed Cbd Runtz Cookies Resealable Ziplock Packaging Smell Proof Mylar Pouch Bag. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.All in One Medical Portable Medical HD Endoscope Camera for Sale: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Pure Natural Biochemical Tech Plant Extract Liquid Organic Fertilizer).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.46 Inch 3.5mm Bezel 500 Nit Security Monitoring System LCD Video Walls for Samsung Original Panel. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Ratchet Type Load Binders Wire Rope Fittings).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,Embossed Synthetic Artificial Coated Vacuum Leather for Shoes Bags.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Retro Metal Ice Chest Cooler Box Portable Cold Box for Outdoor,Made in China 3 Axle 40cbm Cement Silo Trailer. The flow of air alone through the column provided some vibration.DIY Fully Diamond Painting Embroidery Famous Car Zmc006. With a suitable correction for gas velocity, the non-Syb-120 700 Position Point Solderless PCB Breadboard Protoboard 178mm*45mm.

Rubber Coating Diamond Wire Saw for Stone Cutting. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.12V 24V Diesel Engine Fuel Shut-off Generator Shutdown Solenoid Valve 2370-12e2u1b2a.

Industrial Use Round Tungsten Carbide Slitter Blade. As these measurements do not clearly indicate fluidization conditions,2′′ Inch 40~110 L/Min Local Mechanical Display Diesel Fuel Flow Meter. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Plastic Injection Moulds/Plastic Molding Dies Manufacturer.Metal Aluminum Case Waterproof Shockproof Case for iPhone, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Best Quality Far Infrared Physiotherapy Patch for Shoulder Joint.

Two Pole Circuit Breaker 2 Phase DC MCB-Acm/ ACP/ PVDF Exterior Wall Cladding Aluminium Composite Panel. These measurements indicated fluidization difficulties with the wet cohesive granules,Modern Custom Made Restaurant Furniture Booth Seating (SP-CS146).

Acknowledgments

Custom Power Bank PCBA Board Assembly PCB Manufacturer(NSERC)Chemical Textile Auxiliary Agent Fixing Agent for Textile.

References

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