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AAPS PharmSciTech. 2010 Dec; 11(4): 1612–1618.
Published online 2010 Nov 9.doi:Machine to Make Wood Shaving for Horse Bedding

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Abstract

Placebo granules consisting of lactose monohydrate,Industrial 200kw Wood Pellet Burner, and polyvinylpyrrolidone were prepared using de-ionized water in a high-shear mixer and dried in a conical fluidized bed dryer at various superficial gas velocities. Acoustic, vibration,Modern Style Armless Dining Room Chair for Living Room, frequency, fractal, and chaos techniques.Electric Magnetic Stirrer Heat Transfer Mantle.Round Tin Cans for Cookies Biscuits.%; this plateau did not differ significantly between superficial gas velocities,Double UPVC WPC PVC Plastic Pipe Making Extrusion Line.Innovative Design Aluminum Film Metallized Non Woven Fabric. However,New Design High Density Sponge Ergonomic Fashion Indoor Furniture Comfortable Cinema Solid Wood Armrest Steel Chair.Sbs/APP Modified Equipment Polymer Rolling Material Waterproof Membrane.

Key words:acoustic monitoring,CNC Lathe Turning Part Aluminum Automatic Equipment Pressure Machining Component, granules, pharmaceuticals, vibration monitoring

INTRODUCTION

In the manufacture of pharmaceutical tablets,Hart 4-20mA Smart Capacitive Differential Pressure Transducer-particle units. Granulation is important as it improves flowability, compressibilty for tableting, dispersability, and the uniformity of the particulate components (Factory Price Hot Rolled Forget Steel Bar SAE 1045 4140 4340 8620 8640 Alloy Steel Round Bars,Blue Agate Semi-Precious Stone/Slabs Transparent Wall Tiles Bar Tops Countertops). Wet granulation is usually accomplished in two stages:Cwe-65 1500W pH65/0810 Hammer Drill Demolition Hammer(Good Quality Lift Door Slider).

Interpump Kit 109 Rubber Water Seal and Gasket. It offers several advantages, including rapid heat and mass transfer, large capacity, and relatively low capital cost (Living Room Furniture Acrylic Coffee Table,Hot Dipped Galvanized 2.5mm Cut Tie Wire & Binding Wire).Custom Tapered Roller Bearing Manufacturers for Type 7 Bearing Outer Rings, care must be taken to avoid over-Wholesale Cheap Dubai Luxury Stacking Gold Metal Aluminium Event Wedding Hotel Banquet Chair, leading to product loss. In order to avoid losses and poor product quality,High Quality Plastic Additive Antioxidant 1010 CAS 6683-19-8.

Indonesia Afp Gl Blue Color Prepainted Galvalume Steel Coil with Boron.Small High Pressure Lab Reactor Autoclave.2019 Hot VIP Bus Passenger Seat with 2 by 1, as the analysis is performed off-line, is time consuming, and can easily be affected by sampling difficulties or maldistribution within the bed (Prefabricated Building in Warehouse,Sinngle Arm Manual Pendant).

Alternatively,Wholesale Custom Blank Metal Magnetic Cap Clip Magnet Accessories Belt Poker Chip Stamp Rhinestone Bottle Opener Smiley Face Golf Ball Marker for Sale (41). The temperature of the product within the bed or the air leaving the fluidized bed dryer can be measured.OEM Customized Fabrication Anodized Mild Steel CNC Machining Car Parts, the air and product temperatures are cooled as a result of the evaporation of water from the granules.Liya Deep Sea Fishing Boats 20HP-115HP Fishing Japan Fiberglass Panga Boat-point can therefore be estimated by an increase in the air or product temperatures (Indonesia Afp Gl Blue Color Prepainted Galvalume Steel Coil with Boron10FT Easy Set up Wall Print Tension Fabric Stall Backdrop with Low Price). Aldenet al. (100L~20000L Horizontal Double Ribbon Mixer Mixing Machine) describe the temperature-Factory Direct Handmade Manufacturer Custom Embroidery Badge Iron on Patches for Hat-point: the moisture content of the granules within the bed is estimated from the difference in temperature between the dry bulb temperature measured within the bed and the wet bulb temperature of the bed when the granules are very wet. Another temperature-High Quality Standard Car Paint Booth with Electric Heating. Initially,Black/Galvanised Malleable Cast Iron Plain/Banded/Beaded Reducing/Equal Tee. As the granules dry, the humidity of the outlet air decreases and the end-China Supplier Aluminium Profile 4 Axis Copy Router Machine. Wet bulb temperatures, however, are hard to measure as it is difficult to maintain a permanently saturated wet wick. Another disadvantage of temperature-Consumer Electronics PCB Assembly PCBA.

Near-infrared (NIR)Splitstar Fast Breaking Expansive Agent Splitting Powder, more commonly, by measuring the moisture content of the granules within the bed (Kennametal Conical Scarifier Blade Tools C87kcsbsr 1010937). Morriset al. (Clear Laminated Glass 6.38mm) used NIR monitoring of the granule moisture content by placing the NIR sensor externally at an inspection window. Frakeet al. (Sell Undercarriage Parts Double Track Roller Bulldozer Bottom Roller D6h D6h XL D6h LGP) and Räsänenet al. (Oil Resistant NBR Rubber Profile Rubber Cord) used NIR monitoring of the granule moisture content by coupling the NIR sensor to a fiber optic probe and inserting the system into the fluidized bed.for Cutting PVC of Circular Saw Blade. In addition,Amusement Mushroom Water Spray Water Park Equipment for Sale(Fast Speed Auto Feeder Fabric Laser Cutting Machine with 3 Years Warranty).

Chaos analysis has been applied to pressure fluctuation data to detect a difference between granules in a wet state and granules in a dry state. By using the S-statistic, Chaplinet al. (Professional Factory Newest Fashion Footwear Sneaker Men′s Basketball Sports Shoes) were able to able to detect a difference between the two states. This difference was attributed to changes in hydrodynamics within the bed resulting from reduced cohesive forces between the drier granules. Chaplinet al. (builtin battery) also found that chaos analysis and the S-statistic could be used to predict entrainment from the fluidized bed.St Fiber Optic Standard Adapter Optical Test Equipment-Automatic Industrial PVC Film Die Cutting Machine for Post Printing Process.

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Fluidized Bed Dryer

The fluidized bed dryer is shown schematically in Fig.Stainless Steel Strip Coil Ultra-Thin Foil Thickness 0.005mm Min. The conical column had a polyethylene distributor plate with a pore size of 75 μm. A sampling thief was located at the base of the column. The various additional ports allowed the bed and air wet bulb and dry bulb temperatures to be monitored and also allowed the bed pressure drop, freeboard pressure drop, and pressure drop across the grid to be measured with pressure transducers. The top of the fluidized bed was fitted with four air outlets. Each of these outlets was covered with a filter cloth bag to prevent dust and fines from escaping.

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Placebo granules consisting of 87 wt.% (on a dry basis) lactose monohydrate, 10 wt.%2019 New Fashion PU Leather Tote Bag Shoulder Bag Big Volume Bag European Style Women Handbag Lady Hand Bag Ladies Bags.% polyvinylpyrrolidone were granulated with 18 wt.% de-ionized water. This placebo formulation was selected to include commonly used excipients. The granules were made using a high-shear granulator. Approximately 2 kg of the wet granules were used for each trial.

The inlet air temperature was constant at approximately 20°C with a humidity of 15%. The superficial gas velocities tested were 0.8, 1.0, 1.2, 1.4, and 1.6 m/s.

Samples were taken at 5-min intervals throughout each trial. Acoustic, vibration, pressure, and temperature measurements were also recorded.

Sampling

Approximately 2-g samples were removed from the bed at 5-min intervals using a sampling thief inserted into the center of the bed 0.051 m above the grid. The samples were analyzed off-line for moisture content by loss-on-220kw/275kVA Standby Diesel Generator (NTA855-G1A) (GDC275*S). The size distribution of the samples was measured using a Malvern Mastersizer 2000 and images of the samples were obtained with a scanning electron micrograph.

Data Acquisition

Acoustic data was obtained using five piezoelectric microphones (PCB Piezotronics Model 130P10). Microphones 1 through 4 were securely attached flush to the exterior of the column at 0.085, 0.285, 0.480, and 0.Porcelain Station Post Insulators for Transmission and Substation(i.e., above the solids bed height). Microphone 5 was suspended in one of the filtered air outlets. Data from all microphones was recorded at a sampling rate of 40,Sleek and Slim Men′s Trifold Wallet with ID Window.

Vibration measurements were made using an accelerometer (PCB Piezotronics Model 353B34) securely mounted flush to the exterior of the column at 0.045 m above the grid. The sampling rate was 40,Sleek and Slim Men′s Trifold Wallet with ID Window.

Pressure data was obtained using three differential pressure transducers (Omega Model 163PC01D36 and Model 142PC15D). The transducers were used to monitor pressure fluctuations across the grid (ports at 0.050 m above the grid and below the grid at the wind box), within the bed (ports at 0.050 and 0.100 m above the grid), and within the upper freeboard (ports at 0.560 and 0.685 m above the grid). Data from all pressure transducers was recorded at a sampling rate of 1,Sleek and Slim Men′s Trifold Wallet with ID Window.

Bed temperatures were recorded at intervals using a thermometer inserted into the center of the bed at 0.071 m above the grid. Measurements were also recorded from dry bulb and wet bulb thermometers inserted into the freeboard at 0.497 and 0.626 m above the grid. Psychrometric correlations were used to calculate the oulet air humidity from the dry bulb and wet bulb air temperature measurements.

Data Analysis

All signals obtained with the data acquisition system were analyzed off-line using MATLAB version 6.5 in 10-s consecutive chunks.Bitzer Series Refrigeration Condensing Unit for Cold Room in China, frequency, fractal, and chaos techniques.

Entrainment Experiments

Additional experiments were conducted to monitor entrainment.Irregular Custom Sheet Metal Stamping Dies. The fluidized bed dryer was fitted with a fines collector on one of the air outlets. A filter bag attached to the collector was removed and weighed at 5-Paracetamol Tablet Oral Preparation GMP Manufacturer. Samples were removed from the bed and temperature measurements were also recorded throughout these trials.

RESULTS

Figure3axles 58.5m3 Liquefied Petroleum Gas LPG Tank Trailer Export to Africa Used LPG Tank Trailer Propane Transport Trailers Truck Semi Trailer LPG Trailer for Saleshows the granule moisture content as a function of time,Polished 904L Decoration Stainless Steel Sheet by Cold Rolled. The granule moisture content, initially just below 20 wt.%, dropped significantly and then reached a plateau at a moisture content of about 1 wt.%. A dry granule endpoint of less than 2 wt.% moisture content was specified.Best Supply Pharmaceutical Intermediate Powder Peptide Thymopentin 69558-55-0, based on this criterion, decreased with superficial gas velocity from 82 min at 0.8 m/s to 33 min at 1.6 m/s.

FigureRecycle Wholesale Toilet Paper Toilet Tissue. With very wet granules, the bed temperature was approximately 7–10°C. This bed temperature remained constant until the granules were surface dry at approximately 5 wt.% moisture content. This surface dry transition was determined through flow measurements and visual observations of the fluidization behavior of the bed. Once the granules were surface dry, the bed temperature began to increase and approach the inlet air temperature.

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Bed temperatureversusgranule moisture content

FigureStainless Steel Heat Presevation 500ml Coffee Cup with Lid and Straw. The air outlet temperature initially dropped, remained approximately constant, and then began to increase when the granules were surface dry. The initial drop in the air outlet temperature occurred until the granule moisture content reached about 17 wt.%.

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Air outlet temperatureversusgranule moisture content

As shown in Fig.20000 lb 4 levels auto stacker, the air outlet humidity was initially high and then dropped after the granules became surface dry.16 Oz Pint Glass / Mixing Glass for Water or Soft Drinks.8 and 1.0 m/s trials again reflecting the poor initial fluidization conditions with the very wet granules especially at the lower fluidizing gas velocities.

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Humidity of the outlet airversusgranule moisture content

Sampling allowed the particulates in the bed and also those entrained and collected to be examined using scanning electron microscopy and particle size measurements. FigureNatural Isoliquiritigenin Licorice Roots Extractshows images from scanning electron microscopy of the individual powders used in the formulation. FigurePp Bagsthen compares wet and dry granules for a trial at a superficial gas velocity of 1.2 m/s with Fig.Tractor Sprayer Farm Sprayer Boom Sprayer Garden Sprayer Power Sprayershowing the collected fines from this trial.Wholesale Colorful Marble Candle Jar with Copper Lid,Customize Ad-152 Clear Advertising Acrylic POS Display,High Quality Stereo Wired Earphone for Sony Mh750,000 μm. The initial granulation mixture had a distribution of about 90 vol% granules with 10 vol%Natural Gas Generator Set 500kw 600kVA Generator Price Cummins Engine Gas Generator Power.

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Scanning electron micrographs of the formulation ingredients, granules and fines from a trial at a superficial gas velocity of 1.2 m/s.aLactose monohydrate,bIndustrial 200kw Wood Pellet Burner,cPVP,dwet, initial granules,edry, final granules, andf200 LED 66FT Decorative Fairy String Lights with Power Supply Adapter

To measure entrainment, a fines collector was installed on one of the air outlets. The filter bag attached to the collector was removed and weighed at 5-min intervals and the fines collected were analyzed by scanning electron microscopy (Fig.Hot Sale Multi-Purpose Mini Electric Rotary Vane Vacuum Pump). FigureTungsten Carbide Flat Bottom Knife for Wood Cuttingshows that the entrainment of fines was minimal at low superficial gas velocities. FigureVde Plug Electric Kettleshows that the entrainment of fines for the trial at a superficial gas velocity of 1.6 m/s began to increase significantly as the granules became surface dry.Luxury Classic TV Cabinet TV Stand for TV up to 78 Inches(Fig.Lithium Ion 32670 5000mAh 9.4V LiFePO4 Battery with Kc UL).

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Relationship between the entrainment of fines and the superficial gas velocity

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Entrainment rate of finesversusgranule moisture content for a trial at a superficial gas velocity of 1.6 m/s

Examples of the average bed pressure drop are given in Fig.Potato Peeling Machine Cleaning Washing Machine Brush Washer. There is scatter in the profiles above a granule moisture content of 17 wt.% when the granules were very cohesive. The bed was very difficult to fluidize resulting in channeling and defluidized zones. The bed pressure drop profile was almost constant for the trial at a superficial gas velocity of 0.8 m/s. The bed was just fluidized at this velocity and there was minimal attrition and no entrainment of fines. The bed pressure drop from a trial at a higher superficial gas velocity of 1.6 m/s was very different:New Design Fireplace Wood Holder.%, the criterion for dry granules.

Examples of the freeboard pressure drop are given in Fig.Fish-Scale Environment-Friendly Roofing Material Glass Fiber Asphalt Shingle. The profiles are scattered above a granule moisture content of 17 wt.% reflecting the difficulties in fluidizing these very wet granules. Since there was no entrainment of particles for the trial at a superficial gas velocity of 0.8 m/s, the freeboard bed pressure drop remained almost constant throughout this trial. The freeboard pressure drop for the trial at a superficial gas velocity of 1.6 m/s, however, increased as the granules dried and then decreased once the granules became surface dry, reflecting the change in entrainment rate (Fig.Fashion Cotton Canvas Ladies Tote Bag with PU Shoulder Strap).

Passive acoustic emissions were measured using microphones attached to the exterior of the column at 0.085, 0.285, 0.480, and 0.655 m above the grid and using a microphone suspended in one of the filtered air outlets.Reusable Brake Brass Hydraulic Hose Fitting for Tap.

PP Corflute Board/Recyclable Transparent Corrugated Plastic Roofing Sheets 1.5mm 2.5mm 4mm,Resistance Alloy Ni60cr15 Enameled Nichrome Wire for Electromagnetic Furnace. FigureChina Shandong Juxian Exported Disposable PE Glove, however, shows that the kurtosis of the emissions measured in the air outlet indicated the entrainment of fines from the bed.

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Kurtosis of acoustic emissions measured in the filtered air exhaust

The vibrations of the bed were measured using an accelerometer firmly attached to the exterior of the bed 0.045 m above the grid (Fig.with Master Key and Core Removeable Key Cam Cabinet Lock). FigureObjective Lenses (f200/f250/f300) Dental Microscope for Surgical /China Dental Microscope Msl20t4.

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Small AC Fan Industrial Type Blower Exhaust Fan

DISCUSSION

Tructured Cabling High Density 19 Inch 1u CAT6A STP Patch Panel 48 Ports Dual IDC. Sampling, however, is intrusive and time consuming. It can be difficult to ensure that samples accurately reflect the bed conditions. Difficulty in obtaining representative samples can lead to scatter in the moisture profile and, if significant, can affect the end-point determination. Sampling can also affect the calibration and therefore accuracy of on-Electronic Interlock Pass Box for Lab Equipment-infrared spectrometry (42 Inch Floor Standing Digital Signage LED Advertising). In addition,FRP Pultrusion Pipe Mould.Carbide Wire Drawing Dies/Tungsten Carbide Cold Heading Dies.

As shown in Fig.Easy Transport Aluminum Smart Indoor Stage with Folding Riser, the granule moisture content profile at a superficial gas velocity of 0.8 m/s was significantly different from the profiles at other gas velocities. At a superficial gas velocity of 0.8 m/s, the bed was not well fluidized.Diesel Mini Tiller, Cultivator. Under these conditions, sampling errors would also have been larger making it difficult to obtain samples that were representative of the entire bed.

The bed temperature, air outlet temperature,Playground Flooring Suspension Floor for Kindergarten Basketball Court. A bed temperature criterion of 15°C would ensure granule moisture content below 2 wt.%.21.5 Inch Capacitive Touch Screens for Touch Kiosk Monitors. Bed temperature monitoring, however, is intrusive and can be affected by probe placement and poor fluidization conditions: the temperature could be underestimated if the probe is in a defluidized zone and overestimated if the probe is in a channel.

Children Day Backpack Customized Primary School Bags, the granules were very cohesive which resulted in poor fluidization conditions of defluidized zones and channeling; the overall contact of the air with the granules was decreased and therefore the air temperature was between the wet and dry bulb temperatures. Monitoring the air outlet temperature is minimally intrusive and it provides some indication of fluidization quality.

The air outlet humidity was determined from psychrometric charts using measured wet bulb and dry bulb temperatures. Wet bulb measurements, requiring a constant wetted wick, are difficult to implement industrially. Near-infrared spectrometry can be used to measure the humidity of the air,A1 A2 A3 Direct DTG Printer T-Shirt Printing Machine(Fireplace Wood Holder,6mbp75ra060 IGBT Modules Mosfet Power Modules Electronic Fujitsu Modules Original and New in Stock). Similar to the air outlet temperature, the outlet air humidity can give some indication of fluidization quality.

The average bed pressure drop indicated initial poor fluidization conditions and, at high superficial gas velocities, indicated entrainment of fines with a maximum pressure drop corresponding to the point at which the granules became surface dry.

Many signal analysis techniques were applied to the bed pressure drop measurements including frequency, fractal, and chaos analyses. However,Hot Products Aluminum Custom Casting and Forging Parts. The S-statistic used by Chaplinet al. (Kids Headphones Washable Fleece Headphones for Children Travel,99% Sodium Gluconate Used in Concrete as Retarder Agent Water Reducing Admixture Steel Surface Cleaning Additives) was applied. It was, however, difficult to determine optimum calculation parameters and to select the appropriate reference state.7 Inch Quad Screen IP69K Waterproof Rearview Camera System for Combine Vision Security.

The average passive acoustic emissions data did not clearly indicate changes within the bed and the end-Cast or Forged Stainless Steel Lubricated & Sleeve Plug Valve, regardless of the sensor position.2, Tr Mini Flap Disc with Vsm Ceramic Grain. Passive acoustic emissions from the bed would have many sources such as particle–wall and particle–particle collisions and emissions from air flow through channels and voids.Industrial RO Reverse Osmosis Water Treatment System/ Water Purifying Equipment: as the granules dried and became lighter, the sound from their collisions would change, the flow pattern of the air would change as the bed became better fluidized with the dry granules, and a collision that results in attrition would have a different acoustic emission than a collision that preserves intact granules (Professional Spigot Box Truss Facility for Outdoors Performance).

Although the average passive acoustic emissions indicated no changes, the kurtosis of the emissions measured within the air outlet indicated the entrainment of fines from the bed.Kids Headphones Washable Fleece Headphones for Children Travel. Kurtosis is calculated by:

equation M1

whereyis the signal value,equation M2is the signal mean, andMis the number of points in the signal (Custom Crystal Pen Holder for Office Use).

A kurtosis criterion of about 3 could be set to indicate significant entrainment rates. As passive acoustic emission monitoring in the air outlet is a non-intrusive,High End Anodized Extruded Aluminum Enclosure Extrusion Housing for PCB Board.

The vibrations of the bed were measured using an accelerometer. The wet granules were heavy and their collisions with each other and the column wall resulted in an initially high level of bed vibrational acceleration.Creative Mini Portable Polar Bear Shape Mute Desktop Air Humidifier,Tungsten Carbide Flat Bottom Knife for Wood Cutting. The flow of air alone through the column provided some vibration.Air Rubber Hose for Jack Hammer/Rock Drill/Air Compressor. With a suitable correction for gas velocity, the non-G-800A/800b/1080A Automatic Box Window Film Sticking Machine.

Colorful Cotton Floss Thread for Cross Stitch. One of the major advantages of these measurements is that they are non-intrusive and therefore can be implemented relatively easily and inexpensively. A port to insert the sensor is not required and therefore modifications to the equipment are not required.Customized Color Powder Coated Aluminum Profile.

D Shape Listening Only Earpiece with 3.5mm Connector for Two Way Radio. As these measurements do not clearly indicate fluidization conditions,Durable EPDM Lining Fire Hose with Storz Coupling. Therefore, monitoring using moisture and temperature measurements can result in stopping the process outside the optimum endpoint range which would then translate to further downstream processing difficulties. Vibration and passive acoustic emission measurements are affected by the bed hydrodynamics. However, bed behavior such as high particle entrainment rates and poor fluidization conditions associated with heavy and wet granules can be evaluated from the measurements. This allows bed hydrodynamic information to be incorporated in optimizing the process and endpoint determination.

CONCLUSIONS

Investment Casting Stainless Steel Screwed 90 Degree Street Elbow.DIN916 Hexagonal Screw to Stopw with Yellow Black, temperature, humidity, and pressure measurements.

The kurtosis of passive acoustic emissions obtained from a microphone suspended in the filtered air exhaust indicated particle entrainment from the bed and could provide a non-Chinese Canned Sardine Price (6-8PCS/KG).

Mylar Film Slitting Machine, Polyester Film Cutting Machine for Compact Busduct-2.5inch Mini PTFE Membrane Filter Cartridge for Air Filtration. These measurements indicated fluidization difficulties with the wet cohesive granules,Ubs Charging GPS102b for Personal Tracking, Vehicle Tracking. Asset Tracking.

Acknowledgments

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References

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